Ma Shitang, Hou Jiafu, Liu Shijuan, Zhu Fucheng, Wei Peipei, Feng Chengtao, Chen Naidong
College of biological and pharmaceutical engineering, West Anhui University, Lu'an, China.
Mudanjiang Medical University, Mudanjiang, China.
Med Res Arch. 2023 Feb;11(2). doi: 10.18103/mra.v11i2.3559. Epub 2023 Jan 28.
The need for therapeutics to overcome development of existing diseases research to discover new lead agents. In the face of public health challenges worldwide, natural medicines play a pivotal role in innovative lead drug discovery. Network pharmacology can easily construct complicated poly-pharmacology network based on lead compound, biological function, and bioactive target proteins, which meets the overall feature of natural medicines, and enable to elucidate the action mechanism at molecule-protein level with systematic view. In this work, we first summarized the recent progress delineating lead drug development and its interaction with natural medicines. Second, we focused on the relationship between natural medicines and network pharmacology. Additionally, we discussed current issues and potential prospects for the lead drug discover from natural medicines by network pharmacology. Further investigations should be focus on relevant structural analysis for biological experiment, also the dynamic and quantitative network development. In summary, it is a rational approach for innovative lead drug discovery, and with the development of structure and biology research, this approach makes it a very powerful method for the lead molecules in a high-throughput manner from a comprehensive and powerful special multi-compound to target protein/disease poly pharmacology network.
治疗方法需要克服现有疾病的发展，开展研究以发现新的先导药物。面对全球公共卫生挑战，天然药物在创新先导药物发现中发挥着关键作用。网络药理学能够基于先导化合物、生物学功能和生物活性靶蛋白轻松构建复杂的多药理学网络，这符合天然药物的整体特征，并能够从系统的角度阐明分子-蛋白水平的作用机制。在这项工作中，我们首先总结了近期在描述先导药物开发及其与天然药物相互作用方面的进展。其次，我们重点关注了天然药物与网络药理学之间的关系。此外，我们讨论了通过网络药理学从天然药物中发现先导药物的当前问题和潜在前景。进一步的研究应聚焦于生物实验的相关结构分析，以及动态和定量网络的发展。总之，这是一种创新先导药物发现的合理方法，随着结构和生物学研究的发展，这种方法使其成为一种非常强大的方法，能够以高通量方式从全面且强大的特殊多化合物到靶蛋白/疾病多药理学网络筛选先导分子。
