Gonzales Gerard Bryan, Brals Daniella, Sonko Bakary, Sosseh Fatou, Prentice Andrew M, Moore Sophie E, Koulman Albert
Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Stippeneng 4, Wageningen, 6708 WE, Netherlands.
Laboratory of Gastroenterology, Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium.
Sci Adv. 2021 Sep 17;7(38):eabj1132. doi: 10.1126/sciadv.abj1132.
Growth faltering in children arises from metabolic and endocrine dysfunction driven by complex interactions between poor diet, persistent infections, and immunopathology. Here, we determined the progression of the plasma lipidome among Gambian children ( = 409) and assessed its association with growth faltering during the first 2 years of life using the panel vector autoregression method. We further investigated temporal associations among lipid clusters. We observed that measures of stunting, wasting, and underweight are dynamically associated with each other and that lipid groups containing polyunsaturated fatty acids (PUFAs) and phosphatidylcholines consistently predict future growth outcomes. Linear growth was dynamically associated with the majority of lipids, indicating a higher nutritional demand to improve height compared to weight among growth-restricted children. Our results indicate a critical role for PUFAs and choline in early life dietary interventions to combat the child growth faltering still so prevalent in low-income settings.
儿童生长发育迟缓源于不良饮食、持续性感染和免疫病理学之间复杂相互作用所驱动的代谢和内分泌功能障碍。在此，我们确定了冈比亚儿童（n = 409）血浆脂质组的变化，并使用面板向量自回归方法评估了其与生命最初2年生长发育迟缓的关联。我们进一步研究了脂质簇之间的时间关联。我们观察到，发育迟缓、消瘦和体重不足的指标相互之间存在动态关联，并且含有多不饱和脂肪酸（PUFA）和磷脂酰胆碱的脂质组始终能预测未来的生长结果。线性生长与大多数脂质存在动态关联，这表明在生长受限的儿童中，与体重相比，改善身高需要更高的营养需求。我们的结果表明，多不饱和脂肪酸和胆碱在早期饮食干预中起着关键作用，以应对低收入环境中仍然普遍存在的儿童生长发育迟缓问题。
