Issitt P D
Prog Clin Pathol. 1978;7:137-63.
As is apparent from the length of this review, a multitude of laboratory investigations can be performed on the blood of patients with AIHA and CHD. Unfortunately, because of the considerable complexity of some of these tests, their significance is not always apparent to the physician who treats the patient. Communication gaps between the laboratory scientist and the physician at the bedside are bound to occur because of the high degree of specialization of both immunohematology and medical care. The purpose of this review has been to bridge the communication gap. The agents that cause AIHA and CHD are antibodies. Although they are often autoantibodies of complex specificity, usually reacting with all normal red cells, they nevertheless obey most of the rules explaining the action of alloantibodies that sometimes complicate transfusion therapy. By approaching AIHA and CHD as antibody-induced conditions, and by regarding autoantibodies as similar in their actions to alloantibodies, hopefully, physicians will appreciate the significance of the tests performed in the laboratory. For their part, the laboratory workers will be able not only to report test results but also to explain the findings. This review may aid in establishing the essential dialogue.
从这篇综述的篇幅可以明显看出，针对自身免疫性溶血性贫血（AIHA）和冷凝集素病（CHD）患者的血液，可以进行大量的实验室检查。不幸的是，由于其中一些检查相当复杂，其意义对于治疗患者的医生来说并不总是显而易见的。由于免疫血液学和医疗护理的高度专业化，实验室科学家和床边医生之间必然会出现沟通差距。这篇综述的目的就是弥合这种沟通差距。引发AIHA和CHD的因素是抗体。尽管它们通常是具有复杂特异性的自身抗体，通常与所有正常红细胞发生反应，但它们仍然遵循大多数解释同种抗体作用的规则，而同种抗体有时会使输血治疗变得复杂。通过将AIHA和CHD视为抗体诱导的病症，并将自身抗体的作用视为与同种抗体相似，有望使医生认识到实验室检查的意义。就实验室工作人员而言，他们不仅能够报告检查结果，还能够解释检查结果。这篇综述可能有助于建立必要的对话。
