Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University/National Children's Medical Center, Beijing 100045, China (Hu Y, Email: huyan1302@sina. com).
Zhongguo Dang Dai Er Ke Za Zhi. 2021;23(9):927-932. doi: 10.7499/j.issn.1008-8830.2106126.
To study the association of animal protein diet with the recurrence of Henoch-Schönlein purpura (HSP)/skin rash and the risk factors for recurrence of HSP.
A prospective analysis was performed for 121 children with HSP who were admitted to the Beijing Children's Hospital from October to December 2020. The children were given the doctor's advice of the same diet (animal protein diet could be added after 1 week without new-onset skin rash). Follow-up was performed at the outpatient service for half a year. According to the presence or absence of animal protein intake, the children were divided into an observation group with 65 children and a control group with 56 children. The times of skin rash recurrence, the incidence of HSP recurrence, and the incidence of kidney injury were compared between the two groups. According to the presence or absence of recurrence, the children were divided into a recurrence group with 32 children and a non-recurrence group with 89 children. A questionnaire on food frequency was used to record the daily intake of animal protein in the two groups. A multivariate logistic regression analysis was used to identify the risk factors for recurrence of HSP in children.
There was no significant difference between the observation and control groups in the times of skin rash recurrence, the incidence rate of HSP recurrence, and the incidence rate of kidney injury (>0.05). There was no significant difference in the daily intake of animal protein between the recurrence and non-recurrence groups (>0.05). The multivariate logistic regression analysis showed that presence of kidney injury at initial onset, respiratory infection after cure for the first time, and lack of exercise control after cure for the first time were independent risk factors for the recurrence of HSP in children (<0.05).
There is no significant association between animal protein diet and the recurrence of HSP or skin rash. Timely treatment of kidney injury, avoidance of infection after cure, and limitation of strenuous exercise may help to reduce the recurrence rate of HSP in children. .
研究动物蛋白饮食与过敏性紫癜（HSP）/皮疹复发的关系及 HSP 复发的危险因素。
对 2020 年 10 月至 12 月北京儿童医院收治的 121 例 HSP 患儿进行前瞻性分析。患儿均给予相同饮食医嘱（无新发皮疹 1 周后可添加动物蛋白饮食）。门诊随访半年。根据是否摄入动物蛋白饮食将患儿分为观察组 65 例和对照组 56 例。比较两组患儿皮疹复发次数、HSP 复发率、肾损伤发生率。根据是否复发将患儿分为复发组 32 例和未复发组 89 例。采用食物频数问卷记录两组患儿每日动物蛋白摄入量。采用多因素 logistic 回归分析识别 HSP 患儿复发的危险因素。
观察组与对照组皮疹复发次数、HSP 复发率、肾损伤发生率比较，差异均无统计学意义（>0.05）。复发组与未复发组患儿每日动物蛋白摄入量比较，差异无统计学意义（>0.05）。多因素 logistic 回归分析显示，初发时存在肾损伤、首次治愈后发生呼吸道感染、首次治愈后缺乏运动控制是 HSP 患儿复发的独立危险因素（<0.05）。
动物蛋白饮食与 HSP 复发或皮疹复发无明显相关性。及时治疗肾损伤、避免治愈后感染、限制剧烈运动可能有助于降低 HSP 患儿的复发率。
