Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China; School of Laboratory Medicine, Zunyi Medical University, Zunyi, China.
School of Laboratory Medicine, Zunyi Medical University, Zunyi, China.
J Infect Chemother. 2022 Feb;28(2):283-285. doi: 10.1016/j.jiac.2021.09.004. Epub 2021 Sep 15.
Gonococcal meningitis is an exceedingly rare infectious disease, and if not diagnosed and treated in time, it can be severe. We present a case of gonococcal meningitis occurring in a 31-year old healthy woman. She was admitted with fever and persistent headache without urogenital symptoms. Blood cultures were positive and identified as N.gonorrhoeae, but CSF and cervical secretions cultures were both negative. Further testing confirmed the presence of N.gonorrhoeae by 16S ribosomal gene amplification and sequencing in all samples. These results suggest that the case may be a disseminated infection caused by untreated gonorrhea. Our case also shows that nucleic acid detection plays an important role in the rapid and precise diagnosis of gonococcal meningitis and in finding the origin of the pathogen.
淋菌性脑膜炎是一种极为罕见的传染病，如果不能及时诊断和治疗，可能会很严重。我们报告了一例发生在 31 岁健康女性中的淋菌性脑膜炎。她因发热和持续性头痛而入院，无泌尿生殖系统症状。血培养阳性，鉴定为淋病奈瑟菌，但脑脊液和宫颈分泌物培养均为阴性。进一步的检测通过所有样本的 16S 核糖体基因扩增和测序确认了淋病奈瑟菌的存在。这些结果表明，该病例可能是由未经治疗的淋病引起的播散性感染。我们的病例还表明，核酸检测在淋菌性脑膜炎的快速准确诊断以及寻找病原体来源方面发挥着重要作用。
