2015 年 11 月巴黎恐怖袭击后法国普通人群中苯二氮䓬类药物使用的变化：全国 CONSTANCES 队列的中断时间序列分析。

Changes in benzodiazepine use in the French general population after November 2015 terrorist attacks in Paris: an interrupted time series analysis of the national CONSTANCES cohort.

机构信息

Centre Ambulatoire d'Addictologie, AP-HP.Centre-Université de Paris, Hôpital européen Georges-Pompidou, Paris, France

Centre Ambulatoire d'Addictologie, AP-HP.Centre-Université de Paris, Hôpital européen Georges-Pompidou, Paris, France.

出版信息

BMJ Open. 2021 Sep 17;11(9):e044891. doi: 10.1136/bmjopen-2020-044891.

DOI:10.1136/bmjopen-2020-044891

PMID:34535472

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8451294/

Abstract

OBJECTIVES

To determine whether the terrorist attacks occurring in Paris on November 2015 have changed benzodiazepine use in the French population.

DESIGN

Interrupted time series analysis.

SETTING

National population-based cohort.

PARTICIPANTS

90 258 individuals included in the population-based CONSTANCES cohort from 2012 to 2017.

OUTCOME MEASURES

Benzodiazepine use was evaluated according to two different indicators using objective data from administrative registries: weekly number of individuals with a benzodiazepine delivered prescriptions (BDP) and weekly number of defined daily dose (DDD). Two sets of analyses were performed according to sex and age (≤50 vs >50). Education, income and area of residence were additional stratification variables to search for at-risk subgroups.

RESULTS

Among women, those with younger age (incidence rate ratios (IRR)=1.18; 95% CI=1.05 to 1.32 for BDP; IRR=1.14; 95% CI=1.03 to 1.27 for DDD), higher education (IRR=1.23; 95% CI=1.03 to 1.46 for BDP; IRR=1.23; 95% CI=1.01 to 1.51 for DDD) and living in Paris (IRR=1.27; 95% CI=1.05 to 1.54 for BDP) presented increased risks for benzodiazepine use. Among participants under 50, an overall increase in benzodiazepine use was identified (IRR=1.14; 95% CI=1.02 to 1.28 for BDP and IRR=1.12; 95% CI=1.01 to 1.25 for DDD) and in several strata. In addition to women, those with higher education (IRR=1.22; 95% CI=1.02 to 1.47 for BDP), lower income (IRR=1.17; 95% CI=1.02 to 1.35 for BDP) and not Paris residents (IRR=1.13; 95% CI=1.02 to 1.26 for BDP and IRR=1.13; 95% CI=1.03 to 1.26 for DDD) presented increased risks for benzodiazepine use.

CONCLUSION

Terrorist attacks might increase benzodiazepine use at a population level, with at-risk subgroups being particularly concerned. Information and prevention strategies are needed to provide appropriate care after such events.

摘要

目的

确定 2015 年 11 月巴黎发生的恐怖袭击事件是否改变了法国人口中苯二氮䓬类药物的使用情况。

设计

中断时间序列分析。

设置

全国基于人群的队列。

参与者

2012 年至 2017 年期间，来自基于人群的 CONSTANCES 队列的 90258 名个体。

结局指标

使用来自行政登记处的客观数据，根据两个不同的指标评估苯二氮䓬类药物的使用情况：每周开具苯二氮䓬类药物处方的个体数量（BDP）和每周规定日剂量（DDD）。根据性别和年龄（≤50 岁与>50 岁）进行了两组分析。教育、收入和居住地是搜索高危亚组的附加分层变量。

结果

在女性中，年龄较小（BDP 的发病率比（IRR）=1.18；95%CI=1.05 至 1.32；DDD 的 IRR=1.14；95%CI=1.03 至 1.27）、受教育程度较高（BDP 的 IRR=1.23；95%CI=1.03 至 1.46；DDD 的 IRR=1.23；95%CI=1.01 至 1.51）和居住在巴黎（BDP 的 IRR=1.27；95%CI=1.05 至 1.54）的人使用苯二氮䓬类药物的风险增加。在 50 岁以下的参与者中，发现苯二氮䓬类药物的使用总体增加（BDP 的 IRR=1.14；95%CI=1.02 至 1.28；DDD 的 IRR=1.12；95%CI=1.01 至 1.25），并且在多个亚组中也是如此。除了女性，受教育程度较高（BDP 的 IRR=1.22；95%CI=1.02 至 1.47）、收入较低（BDP 的 IRR=1.17；95%CI=1.02 至 1.35）和非巴黎居民（BDP 的 IRR=1.13；95%CI=1.02 至 1.26；DDD 的 IRR=1.13；95%CI=1.03 至 1.26）使用苯二氮䓬类药物的风险增加。