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加拿大安大略省 COVID-19 大流行前后医生苯二氮䓬类药物自我使用情况:基于人群的队列研究。

Physician benzodiazepine self-use prior to and during the COVID-19 pandemic in Ontario, Canada: a population-level cohort study.

机构信息

Department of Family Medicine, University of Ottawa, Ottawa, Ontario, Canada

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

出版信息

BMJ Open. 2023 Apr 21;13(4):e062742. doi: 10.1136/bmjopen-2022-062742.

Abstract

OBJECTIVES

The aim of this study was to investigate physician benzodiazepine (BZD) self-use pre-COVID-19 pandemic and to examine changes in BZD self-use during the first year of the pandemic.

DESIGN

Population-based retrospective cohort study using linked routinely collected administrative health data comparing the first year of the pandemic to the period before the pandemic.

SETTING

Province of Ontario, Canada between March 2016 and March 2021.

PARTICIPANTS

INTERVENTION: Onset of the COVID-19 pandemic in March 2020.

OUTCOMES MEASURES

The primary outcome measure was the receipt of one or more prescriptions for BZD, which was captured via the Narcotics Monitoring System.

RESULTS

In a cohort of 30 798 physicians (mean age 42, 47.8% women), we found that during the year before the pandemic, 4.4% of physicians had 1 or more BZD prescriptions. Older physicians (6.8% aged 50+ years), female physicians (5.1%) and physicians with a prior mental health (MH) diagnosis (12.4%) were more likely than younger (3.7% aged <50 years), male physicians (3.8%) and physicians without a prior MH diagnosis (2.9%) to have received 1 or more BZD prescriptions. The first year of the COVID-19 pandemic was associated with a 10.5% decrease (adjusted OR (aOR) 0.85, 95% CI: 0.80 to 0.91) in the number of physicians with 1 or more BZD prescriptions compared with the year before the pandemic. Female physicians were less likely to reduce BZD self-use (aOR=0.90, 95% CI: 0.83 to 0.98) compared with male physicians (aOR=0.79, 95% CI: 0.72 to 0.87, p=0.046 during the pandemic. Physicians presenting with an incident MH visit had higher odds of filling a BZD prescription during COVID-19 compared with the prior year.

CONCLUSIONS

Physicians' BZD prescriptions decreased during the first year of the COVID-19 pandemic in Ontario, Canada. These findings suggest that previously reported increases in mental distress and MH visits among physicians during the pandemic did not lead to greater self-use of BZDs.

摘要

目的

本研究旨在调查 COVID-19 大流行前医生苯二氮䓬类药物(BZD)的自我使用情况,并研究大流行第一年 BZD 自我使用的变化。

设计

使用链接的常规收集行政健康数据的基于人群的回顾性队列研究,将大流行第一年与大流行前时期进行比较。

地点

加拿大安大略省,2016 年 3 月至 2021 年 3 月。

参与者

干预措施:COVID-19 大流行于 2020 年 3 月开始。

主要结局指标

主要结局指标是通过麻醉品监测系统获得的一种或多种 BZD 处方。

结果

在一个由 30798 名医生组成的队列中(平均年龄 42 岁,47.8%为女性),我们发现大流行前一年,有 4.4%的医生有 1 种或多种 BZD 处方。年龄较大的医生(50 岁以上的医生为 6.8%)、女性医生(5.1%)和有既往心理健康(MH)诊断的医生(12.4%)比年龄较小的医生(<50 岁的医生为 3.7%)、男性医生(3.8%)和没有既往 MH 诊断的医生(2.9%)更有可能开 1 种或多种 BZD 处方。与大流行前一年相比,COVID-19 大流行的第一年与有 1 种或多种 BZD 处方的医生数量减少了 10.5%(调整后的比值比(aOR)0.85,95%CI:0.80 至 0.91)。与男性医生相比,女性医生减少 BZD 自我使用的可能性较小(aOR=0.90,95%CI:0.83 至 0.98),而男性医生则相反(aOR=0.79,95%CI:0.72 至 0.87,p=0.046)。在大流行期间,出现 MH 就诊的医生开出 BZD 处方的可能性更高。

结论

在加拿大安大略省,COVID-19 大流行期间,医生的 BZD 处方减少。这些发现表明,大流行期间报告的医生精神困扰和 MH 就诊增加并没有导致 BZD 自我使用增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b751/10123848/bac3820cb7e6/bmjopen-2022-062742f01.jpg

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