Institute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany.
Department of Clinical Neurobiology, University Hospital Heidelberg and German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Sci Rep. 2021 Sep 17;11(1):18549. doi: 10.1038/s41598-021-97093-x.
Maladaptive adult neurogenesis in the mammalian brain has been associated with diverse behaviors including disrupted learning, negative mood disorders and psychiatric conditions. However, its functional role in the generation and maintenance of chronic pathological pain has not yet been elucidated. Using an inducible genetic deletion in vivo mouse model, different behavioural paradigms and home cage monitoring systems, we show that an absence of adult neurogenesis does not impact the development of neuropathic injury-induced peripheral nociceptive hypersensitivity, but rather promotes the recovery of pathological pain as well as improves parameters associated with the state of well-being of the injured mice. These results provide a mechanistic insight into the mechanisms of chronic pain and implicate neurogenic processes as a potential therapeutic target for reducing pain and improving the quality of life for patients.
哺乳动物大脑中的适应性成人神经发生与多种行为有关，包括学习障碍、负面情绪障碍和精神疾病。然而，其在慢性病理性疼痛的产生和维持中的功能作用尚未阐明。使用体内诱导型基因缺失的小鼠模型、不同的行为范式和家庭笼监测系统，我们表明，成人神经发生的缺失不会影响神经损伤引起的外周痛觉过敏的发展，而是促进病理性疼痛的恢复，并改善与受伤小鼠的健康状态相关的参数。这些结果为慢性疼痛的机制提供了深入的了解，并暗示神经发生过程可能是减轻疼痛和提高患者生活质量的潜在治疗靶点。
