ETV6-RUNX1 和 RUNX1 直接调节 RAG1 的表达：对儿童 B 细胞急性淋巴细胞白血病白血病发生机制的进一步了解。
ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis.
机构信息
Univ Rennes 1, CNRS, IGDR (Institut de génétique et développement de Rennes) - UMR 6290, Rennes, France.
Univ Brest, Inserm, EFS, UMR 1078, GGB, Brest, France.
出版信息
Leukemia. 2022 Feb;36(2):549-554. doi: 10.1038/s41375-021-01409-9. Epub 2021 Sep 17.
ETV6-RUNX1 and RUNX1 directly promote expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of and the −80 bp promoter of gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an excessive RAG recombinase activity. ETV6-RUNX1 participates directly in two events of the multi-hit ALL leukemogenesis: as an initiating event and as an activator of expression.
ETV6-RUNX1 和 RUNX1 直接促进 表达。ETV6-RUNX1 和 RUNX1 分别优先结合到 基因的-1200bp 增强子和-80bp 启动子，竞争这些结合。ETV6-RUNX1 和 RUNX1 诱导过度的 RAG 重组酶活性。ETV6-RUNX1 直接参与 ALL 白血病发生的两个多打击事件：作为起始事件和 表达的激活剂。
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