防晒霜中的铝是否会导致接触性铝过敏儿童的皮炎：一项重复开放性应用试验研究。
Does aluminium in sunscreens cause dermatitis in children with aluminium contact allergy: A repeated open application test study.
机构信息
National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
出版信息
Contact Dermatitis. 2022 Jan;86(1):9-14. doi: 10.1111/cod.13973. Epub 2021 Oct 1.
BACKGROUND
Parents report that children with aluminium contact allergy and vaccination granulomas may react to aluminium-containing sunscreen following application.
OBJECTIVES
To evaluate whether contact dermatitis develops following repeated application of aluminium-containing sunscreens in children with aluminium sensitization and vaccination granulomas.
METHODS
Sixteen children aged 2-9 years (mean age 5 years) with vaccination granulomas and a positive patch test reaction to aluminium chloride hexahydrate 2%/10% petrolatum completed a blinded repeated open application test (ROAT) with two daily applications of two sunscreens for 14 days. One cream contained aluminium and the other did not. The children served as their own controls.
RESULTS
Sixteen children completed the study. Only one child (6%) had a positive skin reaction during ROAT on day 2 to the sunscreen with aluminium. None reacted to the sunscreen without aluminium.
CONCLUSIONS
Use of aluminium-containing sunscreens may on a case basis lead to allergic contact dermatitis in aluminium allergic children.
背景
家长报告称，对铝接触过敏和接种肉芽肿的儿童在使用后可能会对含铝防晒霜产生反应。
目的
评估在对铝敏感和接种肉芽肿的儿童中重复使用含铝防晒霜是否会引发接触性皮炎。
方法
16 名年龄在 2-9 岁（平均年龄 5 岁）的儿童完成了一项双盲重复开放性应用试验（ROAT），每天使用两种防晒霜各两次，共 14 天。一种乳膏含有铝，另一种则不含有。这些孩子作为自身对照。
结果
16 名儿童完成了该研究。只有 1 名儿童（6%）在 ROAT 第 2 天对含铝防晒霜出现阳性皮肤反应。没有儿童对不含铝的防晒霜产生反应。
结论
在个案基础上，含铝防晒霜的使用可能会导致铝过敏儿童发生过敏性接触性皮炎。
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