From the Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö.
Dermatitis. 2022;33(1):31-35. doi: 10.1097/DER.0000000000000787.
Recently, aluminum chloride hexahydrate (ACH) 10.0% petrolatum (pet) was recommended for patch testing to detect aluminum contact allergy. Aluminum lactate (AL) may be as reliable a test substance as ACH.
We aimed to investigate the frequencies of aluminum allergy when ACH and AL were used in patch testing consecutive patients.
Petrolatum preparations of ACH 10.0% and AL 12.0% were added to the baseline series in 2010-2017. Aluminum chloride hexahydrate 10.0% pet was added to the children baseline series from July 1, 2012, to December 31, 2017.
A total of 5448 patients were patch tested with the extended baseline series and 196 children with the extended children baseline series. Forty-eight of the 5448 adults (0.9%) and 10 of the 196 children (5.1%) were diagnosed with aluminum contact allergy. A significant difference was found between the aluminum allergy frequencies in children and adults patch tested with ACH in 2013-2017 (P < 0.001). The difference between the frequencies of contact allergies for the 2 aluminum salts is not statistically significant.
Patch testing with ACH and AL demonstrated similar contact allergy frequencies. To detect aluminum allergy, patch testing with ACH 10.0% pet is recommended. Aluminum chloride hexahydrate 10.0% pet should be considered for inclusion in baseline series for patch testing adults and children.
最近，六水合氯化铝（ACH）10.0%矿脂（pet）被推荐用于斑贴试验，以检测铝接触过敏。乳酸铝（AL）可能是一种与 ACH 一样可靠的试验物质。
我们旨在研究当 ACH 和 AL 用于连续患者斑贴试验时铝过敏的频率。
2010 年至 2017 年，在基础系列中添加了 10.0%ACH 和 12.0%AL 的矿脂制剂。从 2012 年 7 月 1 日至 2017 年 12 月 31 日，在儿童基础系列中添加了 10.0%ACH 矿脂制剂。
共有 5448 名患者接受了扩展基础系列斑贴试验，196 名儿童接受了扩展儿童基础系列斑贴试验。48 名成年人（0.9%）和 10 名儿童（5.1%）被诊断为铝接触过敏。在 2013-2017 年，接受 ACH 斑贴试验的儿童和成人之间的铝过敏频率存在显著差异（P<0.001）。两种铝盐的接触过敏频率之间没有统计学意义上的差异。
使用 ACH 和 AL 进行斑贴试验显示出相似的接触过敏频率。为了检测铝过敏，建议使用 10.0%ACH 矿脂进行斑贴试验。应考虑将 10.0%ACH 矿脂纳入成人和儿童斑贴试验的基础系列。
