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Impact of Thiopurine Exposure on Immunogenicity to Infliximab Is Negligible in the Setting of Elevated Infliximab Concentrations.

作者信息

Ungaro Ryan C, Colombel Jean-Frederic, Dubinsky Marla C, Jain Anjali, Dervieux Thierry

机构信息

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Prometheus Laboratories, San Diego, CA, USA.

出版信息

Inflamm Bowel Dis. 2022 Mar 30;28(4):649-651. doi: 10.1093/ibd/izab232.

DOI:10.1093/ibd/izab232
PMID:34536078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9122746/
Abstract
摘要

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本文引用的文献

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Effect of IBD medications on COVID-19 outcomes: results from an international registry.IBD 药物对 COVID-19 结局的影响：来自国际注册研究的结果。
Gut. 2021 Apr;70(4):725-732. doi: 10.1136/gutjnl-2020-322539. Epub 2020 Oct 20.
2
Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.NUDT15 基因变异与炎症性肠病患者硫嘌呤诱导的骨髓抑制相关。
JAMA. 2019 Feb 26;321(8):773-785. doi: 10.1001/jama.2019.0709.
3
Combination Therapy With Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy: A Post Hoc Analysis.英夫利昔单抗联合硫唑嘌呤治疗可改善英夫利昔单抗的药代动力学特征和疗效：一项事后分析。
Clin Gastroenterol Hepatol. 2019 Jul;17(8):1525-1532.e1. doi: 10.1016/j.cgh.2018.09.033. Epub 2018 Sep 26.
4
Proactively Optimized Infliximab Monotherapy Is as Effective as Combination Therapy in IBD.英夫利昔单抗单药治疗主动优化与联合治疗在 IBD 中同样有效。
Inflamm Bowel Dis. 2019 Jan 1;25(1):134-141. doi: 10.1093/ibd/izy203.
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JAMA. 2017 Nov 7;318(17):1679-1686. doi: 10.1001/jama.2017.16071.
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American Gastroenterological Association Institute Guideline on Therapeutic Drug Monitoring in Inflammatory Bowel Disease.美国胃肠病学会关于炎症性肠病治疗药物监测的学会指南。
Gastroenterology. 2017 Sep;153(3):827-834. doi: 10.1053/j.gastro.2017.07.032. Epub 2017 Aug 3.
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Concentrations of 6-thioguanine nucleotide correlate with trough levels of infliximab in patients with inflammatory bowel disease on combination therapy.在接受联合治疗的炎症性肠病患者中，6-硫代鸟嘌呤核苷酸的浓度与英夫利昔单抗的谷浓度相关。
Clin Gastroenterol Hepatol. 2015 Jun;13(6):1118-24.e3. doi: 10.1016/j.cgh.2014.12.026. Epub 2015 Jan 3.
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Immunogenicity of monoclonal antibodies against tumor necrosis factor used in chronic immune-mediated Inflammatory conditions: systematic review and meta-analysis.针对慢性免疫介导炎症性疾病的肿瘤坏死因子单克隆抗体的免疫原性：系统评价和荟萃分析。
JAMA Intern Med. 2013 Aug 12;173(15):1416-28. doi: 10.1001/jamainternmed.2013.7430.
9
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N Engl J Med. 2010 Apr 15;362(15):1383-95. doi: 10.1056/NEJMoa0904492.