Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
BMC Cardiovasc Disord. 2021 Sep 18;21(1):454. doi: 10.1186/s12872-021-02260-7.
Platelet-to-lymphocyte ratio (PLR) is an inflammation index suggested to have the prognostic capability in heart failure (HF). We sought to investigate the association of PLR with cardiovascular disease (CVD) mortality and creatinine (Cr) rise among Iranian individuals suffering from acute decompensated HF (ADHF).
This retrospective cohort study was in the context of the Persian Registry Of cardioVascular diseasE/Heart Failure (PROVE/HF) study. 405 individuals with ADHF admitted to the emergency department were recruited from April 2019 to March 2020. PLR was calculated by division of platelet to absolute lymphocyte counts and categorized based on quartiles. We utilized the Kaplan-Meier curve to show the difference in mortality based on PLR quartiles. Cr rise was defined as the increment of at least 0.3 mg/dl from baseline. Cox proportional hazard ratio (HR) was used to investigate the association of PLR with CVDs mortality.
Mean age of participants was 65.9 ± 13.49 years (males: 67.7%). The mean follow-up duration was 4.26 ± 2.2 months. CVDs mortality or re-hospitalization was not significantly associated with PLR status. Multivariate analysis of PLR quartiles showed a minimally reduced likelihood of CVDs death in 2nd quartile versus the first one (HR 0.40, 95% confidence interval (CI) 0.16-1.01, P = 0.054). Cr rise had no remarkable relation with PLR status in neither model.
PLR could not be used as an independent prognostic factor among ADHF patients. Several studies are required clarifying the exact utility of this index.
血小板与淋巴细胞比值（PLR）是一种炎症指标，被认为具有预测心力衰竭（HF）患者预后的能力。本研究旨在探讨 PLR 与伊朗急性失代偿性心力衰竭（ADHF）患者心血管疾病（CVD）死亡率和肌酐（Cr）升高的相关性。
这是一项回顾性队列研究，属于波斯心血管疾病登记/心力衰竭（PROVE/HF）研究。2019 年 4 月至 2020 年 3 月，从急诊科收治的 405 例 ADHF 患者中招募了该研究对象。通过血小板与绝对淋巴细胞计数的比值计算 PLR，并根据四分位距进行分类。我们利用 Kaplan-Meier 曲线显示 PLR 四分位距与死亡率之间的差异。Cr 升高定义为与基线相比至少增加 0.3mg/dl。Cox 比例风险比（HR）用于研究 PLR 与 CVDs 死亡率的相关性。
参与者的平均年龄为 65.9±13.49 岁（男性：67.7%）。平均随访时间为 4.26±2.2 个月。CVDs 死亡率或再住院率与 PLR 状态无显著相关性。PLR 四分位距的多变量分析显示，与第一四分位距相比，第二四分位距发生 CVDs 死亡的可能性略有降低（HR 0.40，95%置信区间（CI）0.16-1.01，P=0.054）。在两种模型中，Cr 升高与 PLR 状态均无显著关系。
PLR 不能作为 ADHF 患者的独立预后因素。需要进一步研究来阐明该指标的确切用途。
