Pathology Department, University Hospital of Saint-Etienne, France.
Pathology Department, University Hospital of Ioannina, Greece.
Pathol Res Pract. 2021 Oct;226:153609. doi: 10.1016/j.prp.2021.153609. Epub 2021 Sep 4.
Cardiac myxomas are rare, predominantly sporadic tumors that can cause heart failure and systematic inflammatory symptoms, and increase the risk of emboli. Their pathophysiology remains poorly understood, but intra-tumoral inflammation and senescence seem to be implicated in it. One of the principal cellular mechanisms implicated in tumor progression is autophagy, largely unknown in myxomas. Thus, our study aimed to investigate the presence of autophagic markers in myxomas and to correlate it with their immune microenvironment.
Twenty-five cardiac myxomas were studied for the autophagic markers LC3B and p62/sequestosome 1 and were compared with markers of the immune microenvironment.
Most myxomas showed expression of both autophagic markers. We found a positive correlation between LC3B and PD-L1, as well as CD163, and a negative correlation between LC3B and CD8, CD20, CD138, and CD117 infiltration.
Our data not only confirm the presence of autophagic markers within cardiac myxomas but also suggest a possible association with their immune microenvironment.
心脏黏液瘤是罕见的、主要为散发性肿瘤，可导致心力衰竭和全身炎症症状，并增加栓塞风险。其病理生理学仍知之甚少，但肿瘤内炎症和衰老似乎与之有关。细胞自噬是肿瘤进展的主要机制之一，在黏液瘤中却鲜为人知。因此，我们的研究旨在探讨黏液瘤中自噬标志物的存在，并将其与免疫微环境相关联。
研究了 25 例心脏黏液瘤中的自噬标志物 LC3B 和 p62/自噬体 1，并与免疫微环境标志物进行了比较。
大多数黏液瘤均表达两种自噬标志物。我们发现 LC3B 与 PD-L1 以及 CD163 呈正相关，而与 CD8、CD20、CD138 和 CD117 浸润呈负相关。
我们的数据不仅证实了心脏黏液瘤中存在自噬标志物，还表明其可能与免疫微环境有关。
