UCL Queen's Square Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom; Queen's Medical Centre Nottingham, Clifton Boulevard, Derby Rd, Nottingham NG7 2UH, United Kingdom.
Institute of Mental Health, Jubilee Campus, University of Nottingham Innovation Park, Triumph Road, Nottingham NG7 2TU, United Kingdom.
Neuroimage Clin. 2021;32:102814. doi: 10.1016/j.nicl.2021.102814. Epub 2021 Sep 9.
Magnetoencephalography (MEG), allows for a high degree temporal and spatial accuracy in recording cortical oscillatory activity and evoked fields. To date, no review has been undertaken to synthesise all MEG studies in Multiple Sclerosis (MS). We undertook a Systematic Review of the utility of MEG in MS.
We identified MEG studies carried out in MS using EMBASE, Medline, Cochrane, TRIP and Psychinfo databases. We included original research articles with a cohort of minimum of five multiple sclerosis patients and quantifying of at least one MEG parameter. We used a modified version of the JBI (mJBI) for case-control studies to assess for risk of bias.
We identified 30 studies from 13 centres involving at least 433 MS patients and 347 controls. We found evidence that MEG shows perturbed activity (most commonly reduced power modulations), reduced connectivity and association with altered clinical function in Multiple Sclerosis. Specific replicated findings were decreased motor induced responses in the beta band, diminished increase of gamma power after visual stimulation, increased latency and reduced connectivity for somatosensory evoked fields. There was an association between upper alpha connectivity and cognitive measures in people with MS. Overall studies were of moderate quality (mean mJBI score 6.7).
We find evidence for the utility of MEG in Multiple Sclerosis. Event-related designs are of particular value and show replicability between centres. At this stage, it is not clear whether these changes are specific to Multiple Sclerosis or are also observable in other diseases. Further studies should look to explore cognitive control in more depth using in-task designs and undertake longitudinal studies to determine whether these changes have prognostic value.
脑磁图（MEG）在记录皮质振荡活动和诱发电场方面具有高度的时间和空间准确性。迄今为止，尚无综述综合评估 MEG 在多发性硬化症（MS）中的应用。我们对 MEG 在 MS 中的应用进行了系统评价。
我们通过 EMBASE、Medline、Cochrane、TRIP 和 Psychinfo 数据库确定了在 MS 中进行的 MEG 研究。我们纳入了原始研究文章，这些文章的队列中至少有 5 名多发性硬化症患者，并量化了至少一个 MEG 参数。我们使用 JBI（mJBI）的修改版本来评估病例对照研究的偏倚风险。
我们从 13 个中心确定了 30 项研究，涉及至少 433 名 MS 患者和 347 名对照。我们发现证据表明，MEG 显示活动异常（最常见的是减少功率调制）、连接减少，并与多发性硬化症的改变临床功能相关。特定的重复发现是β频段运动诱发反应减少，视觉刺激后伽马功率增加减少，体感诱发电场潜伏期延长和连接减少。MS 患者的上α连接与认知测量之间存在关联。总体而言，研究质量中等（平均 mJBI 评分 6.7）。
我们发现 MEG 在多发性硬化症中的应用有证据支持。事件相关设计具有特殊价值，并在中心之间具有可重复性。在现阶段，尚不清楚这些变化是否特定于多发性硬化症，或者是否也可在其他疾病中观察到。进一步的研究应探索使用任务内设计更深入地探索认知控制，并进行纵向研究，以确定这些变化是否具有预后价值。
