Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing,China.
Department of Neurology, Tianjin Medical University Chu Hisen-I Memorial Hospital, Tianjin, China.
Curr Neurovasc Res. 2021;18(4):389-394. doi: 10.2174/1567202618666210917164223.
This study aimed to investigate the clinical value of bispectral index (BIS) monitoring in assessing the consciousness and prognosis of Acute Cerebral Infarction (ACI) patients.
In total, 64 patients who suffered from ACI with consciousness disturbance were enrolled in this study. Glasgow Coma Scale (GCS) was performed to evaluate the consciousness level of ACI patients, and BIS was used to monitor the depth of anesthesia and sedation. Then, patients were divided into good prognosis, poor prognosis and death groups according to Modified Rankin Score (mRS). Discrimination analysis of BIS values and GCS score for the prediction of prognosis was performed using the Receiver Operator Characteristic (ROC) curve.
GCS score and BIS values showed statistically significant differences among the three groups. Spearman rank correlation analysis revealed a significant positive correlation between BIS values and GCS score, while BIS values was negatively related with mRS. The ROC curve of prognosis prediction showed strong prognostic power, with Area Under the Curves (AUCs) between 0.830 and 0.917. Moreover, the AUC of BISmean score was higher than that of BISmax, BISmin and GCS, and BISmean of 74 was the best cut-off point for good prognosis.
BIS directly reflects the degree of consciousness disturbance in ACI patients, and thus accurately predicts the prognosis, indicating potential application values of BIS in clinical practice.
本研究旨在探讨脑电双频指数（BIS）监测在评估急性脑梗死（ACI）患者意识和预后中的临床价值。
共纳入 64 例伴有意识障碍的 ACI 患者。采用格拉斯哥昏迷量表（GCS）评估 ACI 患者的意识水平，BIS 监测麻醉和镇静深度。然后，根据改良 Rankin 评分（mRS）将患者分为预后良好、预后不良和死亡组。采用受试者工作特征（ROC）曲线对 BIS 值和 GCS 评分预测预后的鉴别分析。
GCS 评分和 BIS 值在三组间差异有统计学意义。Spearman 秩相关分析显示，BIS 值与 GCS 评分呈显著正相关，而与 mRS 呈负相关。预后预测 ROC 曲线显示出较强的预后预测能力，曲线下面积（AUCs）在 0.830 到 0.917 之间。此外，BISmean 评分的 AUC 高于 BISmax、BISmin 和 GCS，BISmean 为 74 时为预测良好预后的最佳截断点。
BIS 直接反映 ACI 患者意识障碍程度，从而准确预测预后，提示 BIS 在临床实践中有潜在的应用价值。
