From the Departments of Rheumatology.
Radiology, Selcuk University Faculty of Medicine, Selcuklu, Konya, Turkey.
J Clin Rheumatol. 2022 Mar 1;28(2):e521-e527. doi: 10.1097/RHU.0000000000001788.
BACKGROUND/OBJECTIVE: Behçet disease (BD) is not a single unique entity but a syndrome with different clinical phenotypes that can involve arterial and venous vessels of all sizes. To date, there has been no specific test or serum marker to measure and determine the severity of BD, and diagnosis remains based on clinical findings. This study aimed to assess lower extremity venous wall thickness (VWT) measured by ultrasound and laboratory findings and diagnostic performance in patients with BD.
A total of 106 participants were recruited from the rheumatology department in this single-center, case-control study. Participants meeting the eligibility criteria were divided into healthy controls (n = 52) and BD (n = 54). The VWT values of the common femoral vein, great saphenous vein, and popliteal vein were measured using ultrasonography. Laboratory data were obtained from the electronic registration database. Venous wall thicknesses and laboratory findings in patients with BD and healthy subjects were compared.
Venous wall thickness of the lower extremity veins was higher in the BD group and higher in those with a history of deep vein thrombosis than in those without. The mean leukocyte, monocyte, erythrocyte sedimentation rate (ESR), C-reactive protein, plateletcrit (PCT), red cell distribution width (RDW), mean platelet volume (MPV) values, and monocyte-to-lymphocyte ratio (MLR) were higher in BD patients than in the control group. There was a correlation among increased VWT, ESR, PCT, MPV, RDW, and MLR.
C-reactive protein, ESR, MPV, PCT, MLR, RDW, and VWT can be used to assist in the diagnosis of BD.
背景/目的：贝赫切特病（BD）不是一种单一的独特实体，而是一种具有不同临床表型的综合征，可累及各种大小的动脉和静脉血管。迄今为止，尚无特定的测试或血清标志物来衡量和确定 BD 的严重程度，诊断仍然基于临床发现。本研究旨在评估超声测量的下肢静脉壁厚度（VWT）和实验室发现，并评估其在 BD 患者中的诊断性能。
本单中心病例对照研究共招募了 106 名来自风湿病科的参与者。符合入选标准的参与者分为健康对照组（n=52）和 BD 组（n=54）。使用超声测量股总静脉、大隐静脉和腘静脉的 VWT 值。从电子登记数据库中获取实验室数据。比较 BD 患者和健康受试者的静脉壁厚度和实验室发现。
BD 组下肢静脉壁厚度较高，且有深静脉血栓形成史的患者高于无深静脉血栓形成史的患者。BD 患者的白细胞、单核细胞、红细胞沉降率（ESR）、C 反应蛋白、血小板压积（PCT）、红细胞分布宽度（RDW）、平均血小板体积（MPV）值和单核细胞与淋巴细胞比值（MLR）均高于对照组。VWT 增加与 ESR、PCT、MPV、RDW 和 MLR 之间存在相关性。
C 反应蛋白、ESR、MPV、PCT、MLR、RDW 和 VWT 可用于协助 BD 的诊断。
