Sevik Gizem, Ergelen Rabia, Ergenc Ilkay, Soydemir Efe, Temiz Fatma, Atug Ozlen, Direskeneli Haner, Alibaz-Oner Fatma
Division of Rheumatology, Department of Internal Medicine, School of Medicine, Marmara University, Istanbul, Turkey.
Department of Radiology, School of Medicine, Marmara University, Istanbul, Turkey.
Mediterr J Rheumatol. 2025 May 28;36(2):268-272. doi: 10.31138/mjr.120824.dfh. eCollection 2025 Jun.
OBJECTIVE/AIM: Differentiating the gastrointestinal (GI) involvement of Behçet's disease (BD) and inflammatory bowel diseases (IBD) can be a diagnostic challenge. We previously reported that the wall thickness of the common femoral vein (CFV) is higher in BD patients compared to Crohn's disease (CD) with a limited number of IBD patients with only CD. This study aimed to evaluate the CFV thickness measurement in BD patients and in a larger group of IBD patients including both ulcerative colitis (UC) and CD.
The study included patients with BD (n=117), IBD (n=87, [53 CD, 34 UC]), and healthy gender-matched controls (HC) (n=85). CFV wall thicknesses were measured with Doppler ultrasonography.
Among BD patients, 70 (59.8%) had major organ (48[41.0%] vascular, 21[30.0%] ocular, 11[15.7%] gastrointestinal, and 8[11.4%] neurological) involvement. The mean right CFV thickness was 0.75±0.21 mm, 0.32±0.08 mm, and 0.28±0.13 mm for BD, IBD, and HC, respectively (p<0.001). BD patients had significantly higher CFV wall thicknesses compared to IBD patients and HC (adj. p<0.001 for both), and CFV thicknesses in IBD were comparable to HC (adj.p>0.05). Among BD patients, CFV thicknesses did not differ in patients with and without GI involvement. CFV thicknesses were also similar in patients with CD and UC.
CFV thickness was significantly higher in BD compared to CD and UC patients. These results suggest that the CFV wall thickness measurement may be used in daily practice to differentiate GIBD from IBD.
鉴别白塞病（BD）和炎症性肠病（IBD）的胃肠道受累情况可能是一项诊断挑战。我们之前报道过，与克罗恩病（CD）相比，白塞病患者的股总静脉（CFV）壁厚度更高，不过当时纳入的IBD患者数量有限，且仅包括CD患者。本研究旨在评估白塞病患者以及包括溃疡性结肠炎（UC）和CD在内的更大规模IBD患者群体的CFV厚度测量情况。
本研究纳入了BD患者（n = 117）、IBD患者（n = 87，[53例CD，34例UC]）以及健康的性别匹配对照组（HC）（n = 85）。使用多普勒超声测量CFV壁厚度。
在BD患者中，70例（59.8%）有主要器官受累（48例[41.0%]血管受累, 21例[30.0%]眼部受累, 11例[15.7%]胃肠道受累, 8例[11.4%]神经受累）。BD、IBD和HC患者的右侧CFV平均厚度分别为0.75±0.21毫米、0.32±0.08毫米和0.28±0.13毫米（p<0.001）。与IBD患者和HC相比，BD患者的CFV壁厚度显著更高（两者调整后p均<0.001），IBD患者的CFV厚度与HC相当（调整后p>0.05）。在BD患者中，有胃肠道受累和无胃肠道受累的患者CFV厚度无差异。CD患者和UC患者的CFV厚度也相似。
与CD和UC患者相比，BD患者的CFV厚度显著更高。这些结果表明，CFV壁厚度测量可在日常实践中用于鉴别胃肠道白塞病与IBD。
