青少年特发性关节炎患者中的新型冠状病毒肺炎：发病率与严重程度
COVID-19 in patients with juvenile idiopathic arthritis: frequency and severity.
作者信息
Boyarchuk Oksana, Predyk Lilya, Yuryk Iryna
机构信息
Department of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Regional Children's Hospital, Ternopil, Ukraine.
出版信息
Reumatologia. 2021;59(3):197-199. doi: 10.5114/reum.2021.107590. Epub 2021 Jul 11.
Abstract
The aim of the study was to determine the frequency and the course of COVID-19 infection in children with juvenile idiopathic arthritis (JIA). The study involved 51 patients with JIA aged 2 to 18 years. Evidence of COVID-19 was found in 10 (19.6%) patients with JIA. COVID-19 infection occurred more often in patients with systemic arthritis (OR = 6.1667, 95% CI: 1.2053-31.5511, = 0.0289). The course of COVID-19 infection in patients with JIA was generally similar to the course in the pediatric population, despite immunosuppressive therapy. In 3 out of 10 patients the infection caused an exacerbation of JIA, which required therapy escalation.
摘要
该研究的目的是确定幼年特发性关节炎（JIA）患儿中新型冠状病毒肺炎（COVID-19）感染的频率和病程。该研究纳入了51例年龄在2至18岁的JIA患者。在10例（19.6%）JIA患者中发现了COVID-19感染证据。全身型关节炎患者中COVID-19感染更为常见（比值比=6.1667，95%置信区间：1.2053-31.5511，P=0.0289）。尽管进行了免疫抑制治疗，但JIA患者中COVID-19感染的病程总体上与儿科人群相似。10例患者中有3例感染导致JIA病情加重，需要加强治疗。
相似文献
1
COVID-19 in patients with juvenile idiopathic arthritis: frequency and severity.青少年特发性关节炎患者中的新型冠状病毒肺炎：发病率与严重程度
Reumatologia. 2021;59(3):197-199. doi: 10.5114/reum.2021.107590. Epub 2021 Jul 11.
2
Decreased frequency of allergy in juvenile idiopathic arthritis: Results of a case-control study.幼年特发性关节炎患者过敏发生率降低：一项病例对照研究的结果
Mod Rheumatol. 2021 May;31(3):697-703. doi: 10.1080/14397595.2020.1812820. Epub 2020 Sep 7.
3
Frequency of juvenile idiopathic arthritis and associated uveitis in pediatric rheumatology clinics in Turkey: A retrospective study, JUPITER.土耳其儿科风湿病诊所幼年特发性关节炎及相关葡萄膜炎的频率：回顾性研究，JUPITER。
Pediatr Rheumatol Online J. 2021 Aug 23;19(1):134. doi: 10.1186/s12969-021-00613-2.
4
Uveitis in Juvenile Idiopathic Arthritis: 18-Year Outcome in the Population-based Nordic Cohort Study.幼年特发性关节炎相关葡萄膜炎：基于人群的北欧队列研究 18 年随访结果。
Ophthalmology. 2021 Apr;128(4):598-608. doi: 10.1016/j.ophtha.2020.08.024. Epub 2020 Aug 29.
5
Tofacitinib in juvenile idiopathic arthritis: a double-blind, placebo-controlled, withdrawal phase 3 randomised trial.托法替尼治疗幼年特发性关节炎：一项双盲、安慰剂对照、撤药阶段 3 随机试验。
Lancet. 2021 Nov 27;398(10315):1984-1996. doi: 10.1016/S0140-6736(21)01255-1. Epub 2021 Nov 9.
6
Safety of the COVID-19 vaccination in children with juvenile idiopathic arthritis-A observational study from two pediatric rheumatology centres in Poland.幼年特发性关节炎患儿接种新冠疫苗的安全性——来自波兰两个儿科风湿病中心的观察性研究
Front Pediatr. 2023 Mar 10;11:1103763. doi: 10.3389/fped.2023.1103763. eCollection 2023.
7
Trends in prescription of biological agents and outcomes of juvenile idiopathic arthritis: results of the Dutch national Arthritis and Biologics in Children Register.生物制剂处方趋势和青少年特发性关节炎的结局：荷兰儿童关节炎和生物制剂登记处的结果。
Ann Rheum Dis. 2015 Jul;74(7):1379-86. doi: 10.1136/annrheumdis-2013-204641. Epub 2014 Mar 18.
8
Familial aggregation of juvenile idiopathic arthritis with other autoimmune diseases: Impact on clinical characteristics, disease activity status and disease damage.幼年特发性关节炎伴发其他自身免疫性疾病的家族聚集性：对临床特征、疾病活动状态和疾病损害的影响。
Int J Rheum Dis. 2021 Aug;24(8):1080-1085. doi: 10.1111/1756-185X.14167. Epub 2021 Jun 29.
9
2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis.2021 年美国风湿病学会幼年特发性关节炎治疗指南：寡关节炎、颞下颌关节炎和全身型幼年特发性关节炎的治疗方法。
Arthritis Care Res (Hoboken). 2022 Apr;74(4):521-537. doi: 10.1002/acr.24853. Epub 2022 Mar 1.
10
2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis.2021 年美国风湿病学会幼年特发性关节炎治疗指南：寡关节型、颞下颌关节炎和全身型幼年特发性关节炎的治疗方法。
Arthritis Rheumatol. 2022 Apr;74(4):553-569. doi: 10.1002/art.42037. Epub 2022 Mar 1.
引用本文的文献
1
[SARS-CoV-2 and post-COVID-19 syndrome in paediatric rheumatology: A scoping review].[儿童风湿病中的新型冠状病毒2型及新冠后综合征：一项范围综述]
Rev Colomb Reumatol. 2022 Nov 16. doi: 10.1016/j.rcreu.2022.10.003.
2
Vitamin D status in children with COVID-19: does it affect the development of long COVID and its symptoms?新冠病毒感染儿童的维生素D状况：它是否会影响新冠后长期症状的发生及其症状？
Front Pediatr. 2025 Feb 14;13:1507169. doi: 10.3389/fped.2025.1507169. eCollection 2025.
3
Attempts to identify the molecular cause of autoinflammatory recurrent fever.确定自身炎症性复发性发热分子病因的尝试。
Reumatologia. 2024;62(5):381-388. doi: 10.5114/reum/193903. Epub 2024 Nov 8.
4
Clinical outcomes of tocilizumab therapy in polyarticular and systemic juvenile idiopathic arthritis: a single-center analysis (2018-2022).托珠单抗治疗多关节型和全身型幼年特发性关节炎的临床结果：单中心分析（2018 - 2022年）
Rheumatol Int. 2024 Dec;44(12):2949-2959. doi: 10.1007/s00296-024-05711-4. Epub 2024 Sep 23.
5
Impact of the COVID-19 pandemic on the quality of care for juvenile idiopathic arthritis patients: insights from Thailand.COVID-19 大流行对幼年特发性关节炎患者护理质量的影响：来自泰国的见解。
Orphanet J Rare Dis. 2024 Sep 2;19(1):320. doi: 10.1186/s13023-024-03330-7.
6
Interferon-γ Release Assay in the Assessment of Cellular Immunity-A Single-Centre Experience with mRNA SARS-CoV-2 Vaccine in Patients with Juvenile Idiopathic Arthritis.干扰素-γ释放试验在细胞免疫评估中的应用——青少年特发性关节炎患者接种mRNA SARS-CoV-2疫苗的单中心经验
J Clin Med. 2024 Apr 25;13(9):2523. doi: 10.3390/jcm13092523.
7
Coagulation profile in hospitalized children with COVID-19: pediatric age dependency and its impact on long COVID development.COVID-19 住院患儿的凝血谱：儿科年龄依赖性及其对长新冠发展的影响。
Front Immunol. 2024 Mar 6;15:1363410. doi: 10.3389/fimmu.2024.1363410. eCollection 2024.
8
Autoimmunity and long COVID in children.儿童自身免疫与长期新冠症状
Reumatologia. 2023;61(6):492-501. doi: 10.5114/reum/176464. Epub 2024 Jan 18.
9
Coronavirus disease 2019 (COVID-19) in pediatric patients with autoimmune disorders.儿童自身免疫性疾病患者的 2019 年冠状病毒病（COVID-19）。
Eur J Pediatr. 2023 Jul;182(7):2967-2988. doi: 10.1007/s00431-023-04958-6. Epub 2023 Apr 19.
10
Overlapping clinical features of systemic juvenile idiopathic arthritis and SARS-CoV-2-related multisystem inflammatory syndrome in children.儿童系统性幼年特发性关节炎与SARS-CoV-2相关多系统炎症综合征的重叠临床特征。
Reumatologia. 2023;61(1):63-70. doi: 10.5114/reum/161185. Epub 2023 Mar 8.
本文引用的文献
1
COVID-19 in Children With Rheumatic Diseases in the Spanish National Cohort EPICO-AEP.西班牙全国队列研究EPICO - AEP中风湿性疾病患儿的新冠病毒病
J Rheumatol. 2021 Nov;48(11):1761. doi: 10.3899/jrheum.201548.C1.
2
Pediatrics and COVID-19.儿科学与 COVID-19。
Adv Exp Med Biol. 2021;1318:197-208. doi: 10.1007/978-3-030-63761-3_12.
3
SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?SARS-CoV-2 相关 MIS-C：川崎病病毒和遗传病因的关键？
J Exp Med. 2021 Jun 7;218(6). doi: 10.1084/jem.20210446.
4
Between COVID-19 severity and its prevention - what should rheumatologists be aware of?在新冠病毒疾病的严重程度与其预防之间——风湿病学家应该注意什么？
Reumatologia. 2021;59(1):1-2. doi: 10.5114/reum.2021.103941. Epub 2021 Feb 28.
5
6
Clinical variability of the systemic juvenile idiopathic arthritis course: literature review based on case series.系统性幼年特发性关节炎病程的临床变异性：基于病例系列的文献综述
Reumatologia. 2020;58(6):436-443. doi: 10.5114/reum.2020.102010. Epub 2020 Dec 23.
7
American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 2.美国风湿病学会儿童与 SARS-CoV-2 相关的多系统炎症综合征和儿科 COVID-19 中过度炎症的临床指导：第 2 版。
Arthritis Rheumatol. 2021 Apr;73(4):e13-e29. doi: 10.1002/art.41616. Epub 2021 Feb 15.
8
Severity of COVID-19 and survival in patients with rheumatic and inflammatory diseases: data from the French RMD COVID-19 cohort of 694 patients.COVID-19 严重程度与风湿和炎症性疾病患者的生存：来自法国 RMD COVID-19 队列的 694 例患者的数据。
Ann Rheum Dis. 2021 Apr;80(4):527-538. doi: 10.1136/annrheumdis-2020-218310. Epub 2020 Dec 2.
9
The frequency and clinical course of COVID-19 infection in children with juvenile idiopathic arthritis.幼年特发性关节炎患儿感染新型冠状病毒肺炎的频率及临床病程
Clin Exp Rheumatol. 2020 Nov-Dec;38(6):1271-1272. Epub 2020 Oct 18.
10
COVID-19 in patients with rheumatic disease in Hubei province, China: a multicentre retrospective observational study.中国湖北省风湿性疾病患者的新冠肺炎：一项多中心回顾性观察研究
Lancet Rheumatol. 2020 Sep;2(9):e557-e564. doi: 10.1016/S2665-9913(20)30227-7. Epub 2020 Jul 3.
Zotero 插件