Zhao Ying-Nan, Li Kun, Han Xing-Sheng, Pan Ya-Wen
The Second Medical College of Lanzhou University, Lanzhou, Gansu 730030, P.R. China.
Department of Neurosurgery, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R. China.
Oncol Lett. 2021 Nov;22(5):758. doi: 10.3892/ol.2021.13019. Epub 2021 Sep 2.
Medulloblastoma (MB) is one of the most common malignant tumors of the central nervous system in children. Although surgery, radiotherapy and chemotherapy have resulted in considerable progress in the treatment of this disease, the prognosis of patients with MB remains very poor. Therefore, highly specific molecular targeted treatment, which can improve the therapeutic efficacy and reduce the side effects of MB, has become a research hotspot. In recent years, non-coding RNAs (ncRNAs), which were initially considered to be transcriptional noise, have been shown to possess regulatory functions. A series of ncRNAs have been identified, including microRNAs and circular RNAs, which affect the expression of specific genes in a variety of tumors. These genes lead to the formation of a specific complex of proteins or they directly participate in protein synthesis in order to regulate the occurrence and development of tumors. The aim of the present review article was to summarize the recent research studies that have explored the ability of ncRNAs to regulate the occurrence and development of MB.
髓母细胞瘤（MB）是儿童中枢神经系统最常见的恶性肿瘤之一。尽管手术、放疗和化疗在该疾病的治疗方面取得了显著进展，但MB患者的预后仍然很差。因此，能够提高MB治疗效果并减少其副作用的高度特异性分子靶向治疗已成为研究热点。近年来，非编码RNA（ncRNAs）最初被认为是转录噪音，现已证明具有调控功能。一系列ncRNAs已被鉴定出来，包括微小RNA和环状RNA，它们在多种肿瘤中影响特定基因的表达。这些基因导致形成特定的蛋白质复合物或直接参与蛋白质合成，从而调节肿瘤的发生和发展。本综述文章的目的是总结最近探索ncRNAs调控MB发生和发展能力的研究。
