Arakaki Yoshihisa, Shimoji Yuko, Nakasone Tadaharu, Taira Yusuke, Nakamoto Tomoko, Kudaka Wataru, Mekaru Keiko, Aoki Yoichi
Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara Nishihara Okinawa 903-0215, Japan.
Case Rep Obstet Gynecol. 2021 Sep 9;2021:1737975. doi: 10.1155/2021/1737975. eCollection 2021.
Patients with gynecological malignancies can develop radiation injuries, such as cystitis, proctitis, and soft tissue necrosis which have approved indications for hyperbaric oxygen therapy (HBOT). A 76-year-old Japanese woman with vaginal recurrence of cervical cancer was treated with the high-dose rate interstitial brachytherapy. Twenty-one months after the irradiation, she developed radiation necrosis on the external urethral opening. Two cycles of HBOT were performed. HBOT consisted of delivering 100% oxygen for 60 minutes at 2.4 atmospheres absolute. Pressure exposure was performed once daily, 5 days a week for 6 weeks. Eventually, the necrotic mucosa was completely replaced by the normal mucosa. No adverse effects were observed. We successfully treated a case of late adverse events of radiation therapy with HBOT. It was noninvasive and appears to be a useful treatment option which should be considered standard treatment practice.
妇科恶性肿瘤患者可能会出现放射性损伤，如膀胱炎、直肠炎和软组织坏死，这些疾病已被批准为高压氧治疗（HBOT）的适应症。一名76岁的日本女性，宫颈癌阴道复发，接受了高剂量率组织间近距离放疗。放疗21个月后，她在外尿道口出现放射性坏死。进行了两个疗程的高压氧治疗。高压氧治疗包括在2.4绝对大气压下输送100%的氧气60分钟。压力暴露每天进行一次，每周5天，共6周。最终，坏死的黏膜完全被正常黏膜取代。未观察到不良反应。我们成功地用高压氧治疗了一例放疗晚期不良事件。它是非侵入性的，似乎是一种有用的治疗选择，应被视为标准治疗方法。
