Chencheri Nidheesh, Dirawi Mohammed, Tahir Saja, Shekhy Jwan, Abuhammour Walid
Department of Pediatric Neurology, Al Jalila Children's Specialty Hospital, Dubai, ARE.
Department of Pediatrics, Al Jalila Children's Specialty Hospital, Dubai, ARE.
Cureus. 2021 Aug 14;13(8):e17183. doi: 10.7759/cureus.17183. eCollection 2021 Aug.
Human herpesvirus 6 (HHV-6) is a member of the family. There are two HHV-6 species: HHV-6A and HHV-6B. HHV-6B causes the majority of documented primary infections and reactivation events. In this case series, we illustrate the varied spectrum of clinical and radiological features of HHV-6 encephalitis and its management in children. We have described three cases of HHV-6 encephalitis in the age group between nine months and two years. All had an HHV-6 viral load detected in cerebrospinal fluid (CSF) samples. Two of which are of immunocompetent patients. This case series highlights the importance of including HHV-6 infection as one of the differential diagnoses in a child with suspected central nervous system infection and of considering adding CSF HHV-6 polymerase chain reaction (PCR) test for detection. Increasing awareness of this condition will aid physicians in the timely diagnosis and early treatment of HHV-6 encephalitis.
人类疱疹病毒6型（HHV-6）是该病毒家族的一员。HHV-6有两个亚型：HHV-6A和HHV-6B。HHV-6B引发了大多数已记录的原发性感染和再激活事件。在这个病例系列中，我们阐述了HHV-6脑炎在儿童中的临床和放射学特征的多样范围及其治疗方法。我们描述了3例年龄在9个月至2岁之间的HHV-6脑炎病例。所有病例的脑脊液（CSF）样本中均检测到HHV-6病毒载量。其中2例为免疫功能正常的患者。这个病例系列强调了将HHV-6感染纳入疑似中枢神经系统感染儿童的鉴别诊断之一的重要性，以及考虑增加脑脊液HHV-6聚合酶链反应（PCR）检测以进行诊断的重要性。提高对这种疾病的认识将有助于医生及时诊断和早期治疗HHV-6脑炎。
