Matsushita K, Tanikawa K
Department of Urology, Tokai University Tokyo Hospital, Japan.
Tokai J Exp Clin Med. 1987 Sep;12(3):167-71.
Thirty-six patients with recurrent calcium oxalate nephrolithiasis were selected from the stone clinic. Fourteen were normocalcemic and had normal daily urinary calcium excretion. Among 22 patients with idiopathic hypercalciuria, 10 received thiazide diuretics for the prevention of new stone formation. Single-voided urine samples were collected at the outpatient clinic and 24-hour urine at the patients' homes. In hypercalciuric patients, irrespective of thiazide diuretic therapy, the mean value of the calcium/creatinine concentration ratios of postprandial single-voided urine specimens had a meaningful correlation with the man value of 24-hour urinary calcium excretion rates. Also in hypercalciuric patients with thiazide diuretics, a negative correlation was observed between the calcium/creatinine concentration ratio and the index for urinary saturation with calcium oxalate of a postprandial single-voided urine sample. Thus, in the hypercalciuric stone formers, 24-hour urinary calcium excretion rates and the degree of urinary saturation with calcium oxalate can be estimated from the calcium/creatinine concentration ratios of single-voided urinary samples.
从结石门诊选取了36例复发性草酸钙肾结石患者。14例血钙正常且每日尿钙排泄量正常。在22例特发性高钙尿症患者中，10例接受噻嗪类利尿剂以预防新结石形成。在门诊收集单次排尿的尿液样本，在患者家中收集24小时尿液。在高钙尿症患者中，无论是否接受噻嗪类利尿剂治疗，餐后单次排尿尿液样本中钙/肌酐浓度比值的平均值与24小时尿钙排泄率的平均值均具有显著相关性。同样，在接受噻嗪类利尿剂治疗的高钙尿症患者中，餐后单次排尿尿液样本的钙/肌酐浓度比值与草酸钙尿饱和度指数之间存在负相关。因此，在高钙尿症结石形成者中，可以根据单次排尿尿液样本的钙/肌酐浓度比值来估算24小时尿钙排泄率和草酸钙尿饱和度。
