Matsuo Tomohiro, Ito Hidenori, Mitsunari Kensuke, Ohba Kojiro, Miyata Yasuyoshi
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
Metabolites. 2022 Mar 5;12(3):229. doi: 10.3390/metabo12030229.
To date, few detailed studies have been conducted on the convenient and useful markers for the prevalence of lower urinary tract symptoms (LUTS), including overactive bladder (OAB) and nocturia. A high level of calcium (Ca) excretion (hypercalciuria) is indicative of lifestyle-related diseases such as hypertension, which are associated with the onset of LUTS. Hence, in this study we attempted to clarify the relationship between urinary Ca excretion and OAB, nocturia, and nocturnal polyuria in adults. The present study showed that patients with hypercalciuria frequently experienced OAB, nocturia, and nocturnal polyuria. In addition, this study revealed that the severity of LUTS is significantly associated with urinary Ca excretion and that hypercalciuria is an important risk factor for OAB, nocturia, and nocturnal polyuria.
迄今为止，针对下尿路症状（LUTS），包括膀胱过度活动症（OAB）和夜尿症的患病率，尚未开展过多少便捷且有用的标志物的详细研究。高钙（Ca）排泄水平（高钙尿症）表明存在与生活方式相关的疾病，如高血压，而这些疾病与LUTS的发病有关。因此，在本研究中，我们试图阐明成人尿钙排泄与OAB、夜尿症和夜间多尿之间的关系。本研究表明，高钙尿症患者经常出现OAB、夜尿症和夜间多尿。此外，本研究还揭示，LUTS的严重程度与尿钙排泄显著相关，且高钙尿症是OAB、夜尿症和夜间多尿的重要危险因素。
