Osman Ikram Omar, Levasseur Anthony, Brechard Ludivine, Abdillahi Hassan Iman, Salah Abdillahi Idil, Ali Waberi Zeinab, Delerce Jeremy, Bedotto Marielle, Houhamdi Linda, Fournier Pierre-Edouard, Colson Philippe, Aboubaker Mohamed Houmed, Raoult Didier, Devaux Christian A
IHU Méditerranée Infection, Marseille, France.
Aix-Marseille University, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), MEPHI, Marseille, France.
Front Med (Lausanne). 2021 Sep 1;8:737602. doi: 10.3389/fmed.2021.737602. eCollection 2021.
Since the start of COVID-19 pandemic the Republic of Djibouti, in the horn of Africa, has experienced two epidemic waves of the virus between April and August 2020 and between February and May 2021. By May 2021, COVID-19 had affected 1.18% of the Djiboutian population and caused 152 deaths. Djibouti hosts several foreign military bases which makes it a potential hot-spot for the introduction of different SARS-CoV-2 strains. We genotyped fifty three viruses that have spread during the two epidemic waves. Next, using spike sequencing of twenty-eight strains and whole genome sequencing of thirteen strains, we found that Nexstrain clades 20A and 20B with a typically European D614G substitution in the spike and a frequent P2633L substitution in nsp16 were the dominant viruses during the first epidemic wave, while the clade 20H South African variants spread during the second wave characterized by an increase in the number of severe forms of COVID-19.
自新冠疫情开始以来，位于非洲之角的吉布提共和国在2020年4月至8月以及2021年2月至5月间经历了两波疫情。截至2021年5月，新冠病毒已感染了1.18%的吉布提人口，并导致152人死亡。吉布提设有多个外国军事基地，这使其成为引入不同新冠病毒毒株的潜在热点地区。我们对在两波疫情中传播的53种病毒进行了基因分型。接下来，通过对28个毒株进行刺突蛋白测序和对13个毒株进行全基因组测序，我们发现，具有典型欧洲特征的D614G刺突蛋白替换以及nsp16中常见的P2633L替换的Nexstrain进化枝20A和20B是第一波疫情中的主要病毒，而进化枝20H南非变种在第二波疫情中传播，其特点是新冠重症病例数量增加。
