Department of Materials Science and Engineering, School of Engineering, Shiraz University, 71348-51154 Shiraz, Iran.
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Biomed Res Int. 2021 Sep 9;2021:7343147. doi: 10.1155/2021/7343147. eCollection 2021.
This study was aimed at fabricating and evaluating the physical and bioproperties of nanofast cement (NFC) as a replacement of the MTA. The cement particles were decreased in nanoscale, and zirconium oxide was used as a radiopacifier. The setting time and radiopacity were investigated according to ISO recommendations. Analysis of color, bioactivity, and cytotoxicity was performed using spectroscopy, simulated body fluid (SBF), and MTT assay. The setting time of cement pastes significantly dropped from 65 to 15 min when the particle sizes decreased from 2723 nm to 322 nm. Nanoparticles provide large surface areas and nucleation sites and thereby a higher hydration rate, so they reduced the setting time. Based on the resulting spectroscopy, the specimens did not exhibit clinically noticeable discoloration. Resistance to discoloration may be due to the resistance of zirconium oxide to decomposition. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and infrared spectroscopy (FTIR) examinations of the immersed SBF samples showed apatite formation that was a reason for its suitable bioactivity. The results of cell culture revealed that NFC is nontoxic. This study showed that NFC was more beneficial than MTA in dental restorations.
本研究旨在制备和评估纳米快速水泥（NFC）的物理和生物性能，作为 MTA 的替代品。将水泥颗粒减小到纳米级，并使用氧化锆作为射线阻射剂。根据 ISO 建议研究了凝固时间和射线不透性。使用光谱法、模拟体液（SBF）和 MTT 测定法进行颜色、生物活性和细胞毒性分析。当颗粒尺寸从 2723nm 减小到 322nm 时，水泥浆的凝固时间从 65 分钟显著缩短到 15 分钟。纳米颗粒提供了更大的表面积和成核位点，从而提高了水合速率，因此缩短了凝固时间。根据所得光谱，样品没有表现出临床上明显的变色。耐变色性可能归因于氧化锆对分解的抵抗力。浸入 SBF 样品的扫描电子显微镜（SEM）、X 射线衍射（XRD）和红外光谱（FTIR）检查显示形成了磷灰石，这是其具有合适生物活性的原因。细胞培养的结果表明 NFC 是无毒的。本研究表明，NFC 在牙科修复方面比 MTA 更有益。
