D'Antonio Fabrizia, Kane Joseph P M, Ibañez Agustin, Lewis Simon J G, Camicioli Richard, Wang Huali, Yu Yueyi, Zhang Jing, Ji Yong, Borda Miguel Germán, Kandadai Rukmini Mridula, Babiloni Claudio, Bonanni Laura, Ikeda Manabu, Boeve Bradley F, Leverenz James B, Aarsland Dag
Department of Human Neurosciences Sapienza University of Rome Rome Italy.
Centre for Public Health Queen's University Belfast Belfast UK.
Alzheimers Dement (Amst). 2021 Sep 14;13(1):e12235. doi: 10.1002/dad2.12235. eCollection 2021.
Dementia with Lewy bodies (DLB) research has seen a significant growth in international collaboration over the last three decades. However, researchers face a challenge in identifying large and diverse samples capable of powering longitudinal studies and clinical trials. The DLB research community has begun to focus efforts on supporting the development and harmonization of consortia, while also continuing to forge networks within which data and findings can be shared. This article describes the current state of DLB research collaborations on each continent. We discuss several established DLB cohorts, many of whom have adopted a common framework, and identify emerging collaborative initiatives that hold the potential to expand DLB networks and diversify research cohorts. Our findings identify geographical areas into which the global DLB networks should seek to expand, and we propose strategies, such as the creation of data-sharing platforms and the harmonization of protocols, which may further potentiate international collaboration.
在过去三十年中，路易体痴呆（DLB）研究领域的国际合作显著增加。然而，研究人员在识别能够支持纵向研究和临床试验的大规模多样化样本方面面临挑战。DLB研究界已开始将精力集中在支持联盟的发展与协调上，同时也在继续构建能够共享数据和研究结果的网络。本文描述了各大洲DLB研究合作的现状。我们讨论了几个已建立的DLB队列，其中许多采用了共同框架，并确定了具有扩大DLB网络和使研究队列多样化潜力的新兴合作倡议。我们的研究结果确定了全球DLB网络应寻求扩展到的地理区域，并提出了一些策略，如创建数据共享平台和统一方案，这可能会进一步加强国际合作。
