School of Psychological Sciences and Health, Graham Hills Building, Glasgow, G1 1QE, UK, Universidad Autónoma del Caribe, Programa de Psicología, University of Strathclyde, Barranquilla, Colombia.
Universidad de los Andes, Bogotá, Colombia.
Alzheimers Dement. 2021 Feb;17(2):295-313. doi: 10.1002/alz.12202. Epub 2020 Nov 20.
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.
在拉丁美洲和加勒比国家（LAC），防治痴呆症面临紧迫的挑战，如异质性、多样性、政治不稳定和社会经济差异。在促进知识开放交流的合作环境中，这些问题可以更有效地得到解决。在这项工作中，拉丁美洲和加勒比痴呆症联盟（LAC-CD）提出了一个整合议程，以提供知识转化为行动框架（KtAF）。首先，我们总结了基于证据的策略（流行病学、遗传学、生物标志物、临床试验、非药物干预、网络和转化研究），并将其与当前的全球战略相匹配，以便将区域知识转化为变革性行动。然后，我们描述了关键的复杂性来源（遗传孤立、人群混合、环境因素和有效干预措施的障碍），将它们映射到上述挑战，并提供知识的基本镶嵌体，以实现 KtAF。最后，我们描述了支持知识创造阶段的策略，这是 KtAF 转化影响的基础。
