在人工细胞内对基因组进行转录-翻译。

Transcription-translation of the genome within artificial cells.

机构信息

Department of Biosciences & Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, S2-19, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan.

出版信息

Chem Commun (Camb). 2021 Oct 7;57(80):10367-10370. doi: 10.1039/d1cc04401j.

DOI:10.1039/d1cc04401j

PMID:34541593

Abstract

Here we created artificial cells in which information of the genome of living cells is expressed by the elements encoded in the genome. We confirmed that the system works normally within artificial cells, which paves the way for reconstructing living cells from biomolecules.

摘要

在这里，我们创建了人工细胞，其中活细胞基因组中的信息由基因组中编码的元件来表达。我们证实该系统在人工细胞内正常工作，为从生物分子重建活细胞铺平了道路。