Obstetrics and Gynecology Department, Changzhou Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu, China.
Obstetrics and Gynecology Department, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
Reprod Sci. 2022 Feb;29(2):578-585. doi: 10.1007/s43032-021-00743-8. Epub 2021 Sep 20.
Preeclampsia (PE) is a pregnancy complication commonly characterized by high blood pressure. Although it is generally believed that the placenta is the root cause of PE, the exact pathogenesis is unknown; consequently, there is no standard clinical treatment. Therefore, it is necessary to explore new therapeutic drugs. Several studies have reported that pyrroloquinoline quinone (PQQ) exhibits anti-inflammatory and antioxidative effects. The purpose of this study was to investigate the protective effect of PQQ diet supplementation on PE-like rat models. L-NAME induced PE-like model rats were intraperitonially administrated with PQQ. The results showed that PQQ significantly improved clinical manifestations and pregnancy outcomes of PE-like rats. The levels of related inflammatory and antioxidant markers were also significantly reversed. A mechanism study showed that PQQ may achieve the above therapeutic effects by inhibiting NF-κB and promoting Nrf2 antioxidant pathways. In conclusion, we showed the protective effect of PQQ on PE-like model rats, by improving anti-inflammation and antioxidation effect through the NF-κB-Nrf2 pathway.
子痫前期（PE）是一种常见的妊娠并发症，通常表现为高血压。尽管一般认为胎盘是 PE 的根本原因，但确切的发病机制尚不清楚；因此，临床上没有标准的治疗方法。因此，有必要探索新的治疗药物。有几项研究报道吡咯喹啉醌（PQQ）具有抗炎和抗氧化作用。本研究旨在探讨 PQQ 饮食补充对 PE 样大鼠模型的保护作用。用 L-NAME 腹腔内给药诱导 PE 样模型大鼠，给予 PQQ。结果表明，PQQ 显著改善了 PE 样大鼠的临床表现和妊娠结局。相关炎症和抗氧化标志物的水平也明显逆转。机制研究表明，PQQ 可能通过抑制 NF-κB 并促进 Nrf2 抗氧化途径来实现上述治疗效果。总之，我们通过 NF-κB-Nrf2 通路改善抗炎和抗氧化作用，显示了 PQQ 对 PE 样模型大鼠的保护作用。
