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酸奶可能在体外控制子痫前期孕妇血清诱导的胎盘滋养层细胞中sFlt1和PLGF的水平。

Soyghurt Potentially Controls the Level of sFlt1 and PLGF in Preeclampsia Maternal Serum-Induced Placental Trophoblast Cell in vitro.

作者信息

Khairani Astrid Feinisa, Lantika Uci Ary, Ramadhanti Julia, Bashari Muhammad Hasan, Shalannandia Widad Aghnia, Wikayani Tenny Putri, Achadiyani Achadiyani, Ritonga Mulyanusa Amarullah

机构信息

Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Jatinangor, West Java, Indonesia.

Department of Biomedical Sciences, Faculty of Medicine, Universitas Islam Bandung, Bandung, West Java, Indonesia.

出版信息

J Exp Pharmacol. 2024 Mar 13;16:111-122. doi: 10.2147/JEP.S446961. eCollection 2024.

DOI:10.2147/JEP.S446961
PMID:38504909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10949270/
Abstract

PURPOSE

To observe the effect of soya yoghurt (Soyghurt), which is high in flavonoid substance, on the expression of preeclampsia biomarkers (sFLT-1 and PLGF) on preeclampsia serum-induced trophoblast primary cell culture isolated from placental tissue.

METHODS

The trophoblast primary culture was induced by preeclampsia serum (10%). The Soyghurt treatment was performed with 2.5%, 5%, and 7.5% Soyghurt supernatant concentrations in culture media. The expression of preeclampsia markers, sFLT-1 and PLGF, were evaluated using ELISA.

RESULTS

Expression of sFLT-1 on preeclampsia-induced cell culture treated with Soyghurt was significantly lowered compared to the untreated group (p<0.01). However, no significant difference was observed in the PLGF levels of all groups induced by preeclampsia serum (p>0.05).

CONCLUSION

This study demonstrates the potential effect of Soyghurt's in balancing preeclampsia marker expression by inhibiting the expression of sFLT-1 in preeclampsia serum -induced trophoblast cells.

摘要

目的

观察富含类黄酮物质的大豆酸奶对从胎盘组织分离的子痫前期血清诱导的滋养层原代细胞培养物中子痫前期生物标志物（sFLT-1和PLGF）表达的影响。

方法

用子痫前期血清（10%）诱导滋养层原代培养。在培养基中分别用2.5%、5%和7.5%的大豆酸奶上清液浓度进行大豆酸奶处理。使用酶联免疫吸附测定法评估子痫前期标志物sFLT-1和PLGF的表达。

结果

与未处理组相比，用大豆酸奶处理的子痫前期诱导细胞培养物中sFLT-1的表达显著降低（p<0.01）。然而，子痫前期血清诱导的所有组的PLGF水平均未观察到显著差异（p>0.05）。

结论

本研究证明了大豆酸奶在子痫前期血清诱导的滋养层细胞中通过抑制sFLT-1的表达来平衡子痫前期标志物表达的潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/5da875239022/JEP-16-111-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/e5370560a256/JEP-16-111-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/c7e116dc1228/JEP-16-111-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/dab7421f86c3/JEP-16-111-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/8af6652285e0/JEP-16-111-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/24c16965b7f4/JEP-16-111-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/5da875239022/JEP-16-111-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/e5370560a256/JEP-16-111-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/c7e116dc1228/JEP-16-111-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/dab7421f86c3/JEP-16-111-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/8af6652285e0/JEP-16-111-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/24c16965b7f4/JEP-16-111-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06fd/10949270/5da875239022/JEP-16-111-g0006.jpg

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本文引用的文献

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FASEB J. 2023 Aug;37(8):e23078. doi: 10.1096/fj.202300611R.
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Modulation of NRF2/KEAP1 Signaling in Preeclampsia.子痫前期中 NRF2/KEAP1 信号的调节。
Cells. 2023 Jun 4;12(11):1545. doi: 10.3390/cells12111545.
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Flavonoids exert potential in the management of hypertensive disorders in pregnancy.类黄酮在妊娠高血压疾病的管理中具有潜在作用。
Pregnancy Hypertens. 2022 Aug;29:72-85. doi: 10.1016/j.preghy.2022.06.007. Epub 2022 Jul 2.
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Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model.吡咯喹啉醌对 L-NAME 诱导的子痫前期样大鼠模型的抗炎和抗氧化作用。
Reprod Sci. 2022 Feb;29(2):578-585. doi: 10.1007/s43032-021-00743-8. Epub 2021 Sep 20.
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Astragaloside IV alleviates lipopolysaccharide-induced preeclampsia-like phenotypes via suppressing the inflammatory responses.黄芪甲苷通过抑制炎症反应缓解脂多糖诱导的子痫前期样表型。
Kaohsiung J Med Sci. 2021 Mar;37(3):236-244. doi: 10.1002/kjm2.12313. Epub 2020 Oct 22.
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Role of angiogenic factors in the pathogenesis and management of pre-eclampsia.血管生成因子在子痫前期发病机制及管理中的作用
Int J Gynaecol Obstet. 2018 Apr;141(1):5-13. doi: 10.1002/ijgo.12424. Epub 2018 Jan 16.
7
Vitamin D restores angiogenic balance and decreases tumor necrosis factor-α in a rat model of pre-eclampsia.维生素D可恢复子痫前期大鼠模型的血管生成平衡并降低肿瘤坏死因子-α水平。
J Obstet Gynaecol Res. 2017 Jan;43(1):42-49. doi: 10.1111/jog.13186. Epub 2016 Nov 12.
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Use of serum and urinary soluble sFlt-1 and PLGF in the diagnosis of preeclampsia.血清和尿液中可溶性sFlt-1和胎盘生长因子（PLGF）在子痫前期诊断中的应用。
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Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia.可溶性fms样酪氨酸激酶1促进子痫前期中血管紧张素II的敏感性。
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