Polymer Materials & Engineering Department, School of Materials Science & Engineering, Chang'an University, Xi'an 710064, China.
Electronics Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China.
J Biomed Nanotechnol. 2021 Aug 1;17(8):1510-1524. doi: 10.1166/jbn.2021.3130.
Fenton reaction, a typical inorganic reaction, is broadly utilized in the field of wastewater treatment. Recently In case of its ability to inhibit the growth of cancer cells, it has been frequently reported in cancer treatment. Using the unique tumor microenvironment in cancer cells, many iron-based nanoparticles have been developed to release iron ions in cancer cells to induce Fenton reaction. In this mini review, we outline several different types of iron-based nanoparticles and several main means to enhance Fenton reaction in cancer cells. Finally, we discussed the advantages and disadvantages of iron-based nanoparticles for cancer therapy, prospected the future development of iron-based nanoparticles. It is believed that iron-based nanoparticles can make certain contribution to the cause of human cancer in the future.
芬顿反应是一种典型的无机反应，在废水处理领域得到了广泛的应用。最近，由于其抑制癌细胞生长的能力，它在癌症治疗中经常被报道。利用癌细胞中独特的肿瘤微环境，已经开发出许多基于铁的纳米粒子，以在癌细胞中释放铁离子来诱导芬顿反应。在这篇小型综述中，我们概述了几种不同类型的基于铁的纳米粒子和几种增强癌细胞中芬顿反应的主要方法。最后，我们讨论了基于铁的纳米粒子用于癌症治疗的优缺点，展望了基于铁的纳米粒子的未来发展。相信在未来，基于铁的纳米粒子将为人类癌症事业做出一定的贡献。
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