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Fe(III)/Fe(II) 金属有机纳米粒子在生物医学应用中的最新进展

Recent Advances of Fe(III)/Fe(II)-MPNs in Biomedical Applications.

作者信息

Chen Weipeng, Liu Miao, Yang Hanping, Nezamzadeh-Ejhieh Alireza, Lu Chengyu, Pan Ying, Liu Jianqiang, Bai Zhi

机构信息

The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523700, China.

Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, Dongguan 523808, China.

出版信息

Pharmaceutics. 2023 Apr 23;15(5):1323. doi: 10.3390/pharmaceutics15051323.

DOI:10.3390/pharmaceutics15051323
PMID:37242566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10223096/
Abstract

Metal-phenolic networks (MPNs) are a new type of nanomaterial self-assembled by metal ions and polyphenols that have been developed rapidly in recent decades. They have been widely investigated, in the biomedical field, for their environmental friendliness, high quality, good bio-adhesiveness, and bio-compatibility, playing a crucial role in tumor treatment. As the most common subclass of the MPNs family, Fe-based MPNs are most frequently used in chemodynamic therapy (CDT) and phototherapy (PTT), where they are often used as nanocoatings to encapsulate drugs, as well as good Fenton reagents and photosensitizers to improve tumor therapeutic efficiency substantially. In this review, strategies for preparing various types of Fe-based MPNs are first summarized. We highlight the advantages of Fe-based MPNs under the different species of polyphenol ligands for their application in tumor treatments. Finally, some current problems and challenges of Fe-based MPNs, along with a future perspective on biomedical applications, are discussed.

摘要

金属-酚醛网络（MPNs）是近几十年来迅速发展起来的一类由金属离子和多酚自组装而成的新型纳米材料。由于其环境友好性、高质量、良好的生物粘附性和生物相容性，它们在生物医学领域得到了广泛研究，在肿瘤治疗中发挥着关键作用。作为MPNs家族最常见的子类，铁基MPNs最常用于化学动力学疗法（CDT）和光动力疗法（PTT），在这些疗法中，它们常被用作纳米涂层来封装药物，以及作为良好的芬顿试剂和光敏剂，以大幅提高肿瘤治疗效率。在这篇综述中，首先总结了制备各类铁基MPNs的策略。我们强调了不同种类多酚配体下铁基MPNs在肿瘤治疗应用中的优势。最后，讨论了铁基MPNs目前存在的一些问题和挑战，以及其生物医学应用的未来前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0823/10223096/2b40f4412bf5/pharmaceutics-15-01323-g020.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0823/10223096/55d9c62d57f9/pharmaceutics-15-01323-sch001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0823/10223096/cd1a0660a6b8/pharmaceutics-15-01323-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0823/10223096/f23ab68978b9/pharmaceutics-15-01323-g018.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0823/10223096/2b40f4412bf5/pharmaceutics-15-01323-g020.jpg

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本文引用的文献

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