School of Pharmacy, Nantong University, Nantong, Jiangsu Province 226001, China.
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
ACS Biomater Sci Eng. 2020 Sep 14;6(9):4834-4845. doi: 10.1021/acsbiomaterials.0c01009. Epub 2020 Aug 25.
Chemodynamic therapy (CDT) has aroused extensive attention for cancer treatment in the last five years, as it could suppress tumor progression through in situ detrimental oxidative stress of the tumor cells via the Fenton reaction. Under a tumor acidic microenvironment, the Fenton reaction can be initiated for disproportioning endogenous hydrogen peroxide into highly toxic hydroxyl radical. Taking advantage of the highly tumor-specific therapy modality, various Fenton nanocatalysts have been developed for CDT. In particular, iron-containing Fenton nanocatalysts with minimal cytotoxicity exhibit great promise for clinical translation. In this review, we summarize the recent progress of CDT based on iron-containing nanomaterials, including iron oxide nanoparticles, glassy iron nanoclusters, ferrocene nanoparticles, metal polyphenol networks, metal-organic frameworks, etc. We also discuss the challenges and perspectives for promoting CDT by rational design of iron-containing nanomaterials, highlighting their potential for precise cancer therapy.
化学动力学疗法（CDT）在过去五年中引起了广泛关注，可通过芬顿反应在肿瘤部位产生有害的氧化应激来抑制肿瘤进展。在肿瘤酸性微环境下，芬顿反应可将内源性过氧化氢歧化为高毒性的羟基自由基。利用这种高度肿瘤特异性的治疗方式，已经开发出各种用于 CDT 的芬顿纳米催化剂。特别是具有最小细胞毒性的含铁芬顿纳米催化剂在临床转化方面具有广阔的前景。在这篇综述中，我们总结了基于含铁纳米材料的 CDT 的最新进展，包括氧化铁纳米颗粒、玻璃态铁纳米团簇、二茂铁纳米颗粒、金属多酚网络、金属有机骨架等。我们还讨论了通过合理设计含铁纳米材料来促进 CDT 所面临的挑战和前景，突出了它们在精确癌症治疗方面的潜力。
