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导致免疫抑制患者出现非连续性、多灶性脊椎骨髓炎。

causing non-contiguous, multifocal spondylodiscitis in an immunosuppressed patient.

机构信息

Department of Neurology and Neurosurgery, Rigas Austrumu kliniska universitates slimnica, Riga, Latvia

Department of Neurology and Neurosurgery, Rigas Austrumu kliniska universitates slimnica, Riga, Latvia.

出版信息

BMJ Case Rep. 2021 Sep 20;14(9):e242420. doi: 10.1136/bcr-2021-242420.

DOI:10.1136/bcr-2021-242420
PMID:34544700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8454287/
Abstract

This report describes a case of a spondylodiscitis in an immunocompromised patient with an HIV infection caused by The patient was admitted to hospital with a sudden loss of motor function and sensation in both of the patient's legs. A biopsy taken during the first debridement operation proved to be negative for DNA and growth, but was positive for the growth of Following a course of antibiotic therapy and the aforementioned debridement, the patient was moved to a specialised clinic for physical therapy. The patient's condition quickly deteriorated, and the patient once again required extensive debridement. Repeated spinal surgery, antibiotics for 12 weeks and subsequent rehabilitation resulted in almost complete recovery of sensorimotor limb function.

摘要

本报告描述了一例由 引起的 HIV 感染免疫功能低下患者的脊椎骨髓炎。患者因双下肢突然丧失运动和感觉功能而住院。第一次清创手术时进行的活检结果显示 DNA 及培养均为阴性,但培养出 。经过抗生素治疗和上述清创术治疗后,患者转至专门的理疗诊所。患者的病情迅速恶化,再次需要广泛清创。反复的脊柱手术、12 周的抗生素治疗和随后的康复治疗使四肢感觉运动功能几乎完全恢复。

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本文引用的文献

1
Cutibacterium acnes in shoulder surgery: a scoping review of strategies for prevention, diagnosis, and treatment.肩外科中的痤疮丙酸杆菌:预防、诊断和治疗策略的范围综述。
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2
Spondylodiscitis due to following lumbosacral intradiscal biologic therapy: a case report.腰骶部椎间盘内生物治疗引起的椎间盘炎:一例报告。
Regen Med. 2019 Sep;14(9):823-829. doi: 10.2217/rme-2019-0008. Epub 2019 Aug 19.
3
Spondylodiscitis: is really all well defined?骨与椎间盘炎:真的都明确了吗?
Eur Rev Med Pharmacol Sci. 2019 Apr;23(2 Suppl):201-209. doi: 10.26355/eurrev_201904_17494.
4
C1-C2 arthrodesis after spontaneous spondylodiscitis: Case report and literature analysis.自发性脊椎椎间盘炎后C1-C2关节融合术:病例报告与文献分析
Surg Neurol Int. 2018 Jan 22;9:14. doi: 10.4103/sni.sni_96_17. eCollection 2018.
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and olecranon bursitis/osteomyelitis: a case involving surgical and antibiotic treatment.以及鹰嘴滑囊炎/骨髓炎:一例涉及手术及抗生素治疗的病例。
BMJ Case Rep. 2018 Feb 12;2018:bcr-2017-223782. doi: 10.1136/bcr-2017-223782.
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Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway.痤疮丙酸杆菌通过 TLR2/JNK/线粒体介导的途径促进髓核细胞凋亡诱导椎间盘退变。
Emerg Microbes Infect. 2018 Jan 10;7(1):1. doi: 10.1038/s41426-017-0002-0.
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Post-operative spondylodiscitis due to Propionibacterium acnes: A case report.
Neurochirurgie. 2017 May;63(2):96-98. doi: 10.1016/j.neuchi.2017.01.006. Epub 2017 May 8.
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Spondylodiscitis due to Propionibacterium acnes: report of twenty-nine cases and a review of the literature.痤疮丙酸杆菌相关性椎间盘炎:29 例报告及文献复习。
Clin Microbiol Infect. 2010 Apr;16(4):353-8. doi: 10.1111/j.1469-0691.2009.02801.x. Epub 2009 Jun 6.
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10
Late-onset central nervous system shunt infections with Propionibacterium acnes: diagnosis and management.痤疮丙酸杆菌引起的迟发性中枢神经系统分流感染:诊断与管理
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