Ospedale Maggiore della Carità Hospital, Novara.
Azienda Ospedaliera - Polo Universitario - 'Luigi Sacco', Milan.
J Cardiovasc Med (Hagerstown). 2022 Jan 1;23(1):22-27. doi: 10.2459/JCM.0000000000001189.
The coronavirus disease-19 (COVID-19) outbreak has been recently associated with lower hospitalization rates for acute coronary syndromes. Aim of the study was to investigate whether a similar behaviour is observed in admissions for urgent pacemaker implant.
This retrospective study included 1315 patients from 18 hospitals in Northern Italy with a high number of COVID-19 cases. Hospitalization rates for urgent pacemaker implant were compared between the following periods: 20 February to 20 April 2020 (case period); from 1 January to 19 February 2020 (intra-year control period); from 20 February to 20 April 2019 (inter-year control period).
The incidence rate of urgent implants was 5.0/day in the case period, 6.0/day in the intra-year control period and 5.8/day in the inter-year control period. Incidence rate in the case period was significantly lower than both the intra-year [incidence rate ratio (IRR): 0.81, 95% CI 0.67-0.99, P = 0.040] and inter-year control periods (IRR: 0.79, 95% CI 0.66-0.95, P = 0.012); this reduction was highest after the national lockdown (IRR 0.68, 95% CI 0.52-0.91, P = 0.009). The prevalence of residents in rural areas undergoing urgent pacemaker implant was lower in the case period (36%) than in both the intra-year (47%, P = 0.03) and inter-year control periods (51%, P = 0.002). Elective pacemaker implants also decreased in the case period, with the incidence rate here being 3.5/day vs. 6.4/day in the intra-year (-45%) and 6.9/day in the inter-year period (-49%).
Despite severe clinical patterns, the COVID-19 outbreak has negatively affected the population presentation to Emergency Departments for bradyarrhythmias requiring urgent pacemaker implant in Northern Italy. This mainly occurred after the national lockdown and concerned patients living in rural areas.
新型冠状病毒病-19(COVID-19)的爆发与急性冠状动脉综合征的住院率降低有关。本研究旨在探讨在紧急起搏器植入方面是否存在类似的情况。
本回顾性研究纳入了意大利北部 18 家医院的 1315 名患者,这些医院的 COVID-19 病例较多。比较了以下时期紧急起搏器植入的住院率:2020 年 2 月 20 日至 4 月 20 日(病例期);2020 年 1 月 1 日至 2 月 19 日(同年对照期);2019 年 2 月 20 日至 4 月 20 日(跨年度对照期)。
病例期紧急植入的发病率为 5.0/天,同年对照期为 6.0/天,跨年度对照期为 5.8/天。病例期的发病率明显低于同年对照期[发病率比(IRR):0.81,95%可信区间(CI)0.67-0.99,P=0.040]和跨年度对照期(IRR:0.79,95% CI 0.66-0.95,P=0.012);这种减少在全国封锁后最高(IRR 0.68,95% CI 0.52-0.91,P=0.009)。病例期农村居民接受紧急起搏器植入的比例(36%)低于同年对照期(47%,P=0.03)和跨年度对照期(51%,P=0.002)。病例期的选择性起搏器植入也减少了,其发病率为 3.5/天,同年对照期为 6.4/天(-45%),跨年度对照期为 6.9/天(-49%)。
尽管 COVID-19 爆发的临床症状严重,但在意大利北部,COVID-19 爆发对因缓慢性心律失常而需紧急起搏器植入的人群在急诊科就诊产生了负面影响。这主要发生在全国封锁之后,涉及居住在农村地区的患者。