Silverman W F, Walsh R J
Department of Anatomy, George Washington University Medical Center, Washington, D.C.
Anat Rec. 1987 Jan;217(1):53-5. doi: 10.1002/ar.1092170108.
The present work examines the ability of prolactin to enter the CNS of the rat and effect its feedback stimulation of dopamine release prior to the appearance of prolactin receptors in choroid plexus (i.e., 10 days postnatal). An inhibitor of tyrosine hydroxylase was used to allow the assessment of dopamine turnover separate from synthesis and transport of the amine. Chronic but not acute hyperprolactinemia resulted in increased dopamine release relative to vehicle-treated controls, as shown by diminished fluorescence intensity in the median eminence. These results indicate that activation of the prolactin short-loop feedback system occurs by 10 days postnatal, prior to the appearance of prolactin receptors at the choroid plexus.
本研究探讨了催乳素进入大鼠中枢神经系统的能力，以及在脉络丛中催乳素受体出现之前（即出生后10天），其对多巴胺释放的反馈刺激作用。使用酪氨酸羟化酶抑制剂来评估多巴胺的周转，使其与胺的合成和转运相分离。与用赋形剂处理的对照组相比，慢性而非急性高催乳素血症导致多巴胺释放增加，这在正中隆起处荧光强度降低得到了体现。这些结果表明，催乳素短环反馈系统在出生后10天就被激活，早于脉络丛中催乳素受体的出现。
