磷酸双芳基基序能够使短肽快速酶促自组装和水凝胶化。
Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides.
机构信息
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02453, USA.
Department of Chemistry and Biochemistry, Hampton University, Hampton, VA, 23668, USA.
出版信息
Soft Matter. 2021 Oct 6;17(38):8590-8594. doi: 10.1039/d1sm01221e.
Abstract
Enzyme-instructed self-assembly (EISA) and hydrogelation is a versatile approach for generating soft materials. Most of the substrates for alkaline phosphatase catalysed EISA utilize phosphotyrosine (Tyr) as the enzymatic trigger for EISA and hydrogelation. Here we show the first example of phosphonaphthyl (NP) and phosphobiphenyl (BP) motifs acting as faster enzymatic triggers than phosphotyrosine for EISA and hydrogelation. This work illustrates novel enzyme triggers for rapid enzymatic self-assembly and hydrogelation.
摘要
酶指导的自组装（EISA）和水凝胶化是一种生成软材料的通用方法。大多数碱性磷酸酶催化的 EISA 底物都利用磷酸酪氨酸（Tyr）作为 EISA 和水凝胶化的酶触发物。在这里，我们展示了首例磷萘基（NP）和磷联苯（BP）基序作为 EISA 和水凝胶化比磷酸酪氨酸更快的酶触发物的例子。这项工作说明了用于快速酶自组装和水凝胶化的新型酶触发物。
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