School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
School of Ethnic Medicine, Guizhou Minzu University, Guiyang, 550025, P. R. China.
Org Biomol Chem. 2021 Oct 14;19(39):8487-8491. doi: 10.1039/d1ob01586a.
An efficient and practical approach for the synthesis of medicinally important acridones was developed from anthranils and commercially available arylboronic acids by a tandem copper(I)-catalyzed electrophilic amination/Ag(I)-mediated oxidative annulation strategy. This new and straightforward protocol displayed a broad substrate scope (25 examples) and high functional group tolerance. What's more, a possible mechanistic proposal was also presented.
开发了一种从邻氨基苯甲酸和市售芳基硼酸出发，经串联铜（I）催化的亲电胺化/Ag（I）介导的氧化环化策略合成具有重要药用价值的吖啶酮的有效实用方法。该新方法具有广泛的底物范围（25 个实例）和高官能团容忍度。此外，还提出了一种可能的机理建议。
