铜催化的sp3 C-H键的有氧氧化胺化反应：2-杂芳基喹唑啉-4(3H)-酮的高效合成
Copper-catalyzed aerobic oxidative amination of sp3 C-H bonds: efficient synthesis of 2-hetarylquinazolin-4(3H)-ones.
作者信息
Li Qiang, Huang Yao, Chen Tieqiao, Zhou Yongbo, Xu Qing, Yin Shuang-Feng, Han Li-Biao
机构信息
State Key Laboratory of Chemo/Biosensing and Chemo metrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082, China.
出版信息
Org Lett. 2014 Jul 18;16(14):3672-5. doi: 10.1021/ol501454j. Epub 2014 Jun 30.
An efficient synthesis of 2-hetarylquinazolin-4(3H)-ones via copper-catalyzed direct aerobic oxidative amination of sp(3)C-H bonds has been developed. This tandem oxidation-amination-cyclization transformation represents a straightforward protocol to prepare 2-hetaryl-substituted quinazolinones from easily available 2-aminobenzamides and (2-azaaryl)methanes.
通过铜催化的sp(3)C-H键直接有氧氧化胺化反应，已开发出一种高效合成2-杂芳基喹唑啉-4(3H)-酮的方法。这种串联氧化-胺化-环化转化代表了一种直接的方法，可从容易获得的2-氨基苯甲酰胺和(2-氮杂芳基)甲烷制备2-杂芳基取代的喹唑啉酮。
Zotero 插件