Revilla E, Fabregat I, Santa María C, Machado A
Departamento de Bioquímica, Facultad de Farmacia, Universidad de Sevilla, Spain.
Biochem Int. 1987 May;14(5):957-62.
We have studied the changes in the activity of the pentose phosphate cycle and the malic enzyme produced by the activation or inhibition of different NADPH-consuming pathways. Kynurenate, an acetyl-CoA-carboxylase inhibitor produced a decrease in the flux through the NADPH-producing pathways pentose phosphate cycle and malic enzyme. Acini (isolated from mammary gland) incubated in the presence of ter-butyl-hydroperoxide, a compound which is metabolized via a NADPH-consuming pathway, showed a substantial increase in the pentose phosphate cycle and the malic enzyme pathways.
我们研究了通过激活或抑制不同的NADPH消耗途径所产生的戊糖磷酸循环和苹果酸酶活性的变化。犬尿烯酸，一种乙酰辅酶A羧化酶抑制剂，导致通过产生NADPH的途径（戊糖磷酸循环和苹果酸酶）的通量下降。在叔丁基过氧化氢（一种通过NADPH消耗途径代谢的化合物）存在下孵育的腺泡（从乳腺分离），其戊糖磷酸循环和苹果酸酶途径显示出显著增加。
