Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Mol Cell. 2021 Sep 16;81(18):3878-3878.e1. doi: 10.1016/j.molcel.2021.06.021.
Metabolic networks support cancer cell survival, proliferation, and malignant progression. Cancer cells take up large amounts of nutrients such as glucose and glutamine whose metabolism provides the energy, reducing equivalents, and biosynthetic precursors required to meet the biosynthetic demands of proliferation. Intermediates of glycolysis and the tricarboxylic acid (TCA) cycle provide critical building blocks for synthesis of non-essential amino acids, nucleotides, and fatty acids. To view this SnapShot, open or download the PDF.
代谢网络支持癌细胞的存活、增殖和恶性进展。癌细胞摄取大量的营养物质，如葡萄糖和谷氨酰胺，其代谢提供了满足增殖所需的能量、还原当量和生物合成前体。糖酵解和三羧酸 (TCA) 循环的中间产物为非必需氨基酸、核苷酸和脂肪酸的合成提供了关键的构建模块。要查看此快照，请打开或下载 PDF。
