State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Tianjin Institute of Cardiology, Tianjin Medical University, Tianjin 300070, China; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China.
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Tianjin Institute of Cardiology, Tianjin Medical University, Tianjin 300070, China; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China.
J Mol Cell Cardiol. 2022 Jan;162:158-165. doi: 10.1016/j.yjmcc.2021.09.007. Epub 2021 Sep 20.
Cells are constantly exposed to various mechanical forces, including hydrostatic pressure, cyclic stretch, fluid shear stress, and extracellular matrix stiffness. Mechanical cues can be translated into the cell-specific transcriptional process by a cellular mechanic-transducer. Evidence suggests that mechanical signals assist activated intracellular signal transduction pathways and the relative phenotypic adaptation to coordinate cell behavior and disease appropriately. The Hippo/yes-associated protein (YAP) signaling pathway is regulated in response to numerous mechanical stimuli. It plays an important role in the mechanotransduction mechanism, which converts mechanical forces to cascades of molecular signaling to modulate gene expression. This review summarizes the recent findings relevant to the Hippo/YAP pathway-based mechanotransduction in cell behavior and maintaining blood vessels, as well as cardiovascular disease.
细胞不断受到各种机械力的影响，包括静水压力、循环拉伸、流体剪切力和细胞外基质刚度。细胞机械转导器可以将机械线索转化为细胞特异性的转录过程。有证据表明，机械信号有助于激活细胞内信号转导途径，并相对表型适应，以协调细胞行为和疾病的发生。Hippo/yes 相关蛋白 (YAP) 信号通路受到多种机械刺激的调节。它在机械转导机制中发挥着重要作用，该机制将机械力转化为分子信号级联，以调节基因表达。本综述总结了与 Hippo/YAP 通路相关的机械转导在细胞行为和维持血管以及心血管疾病中的最新发现。
