Department of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Pathol Res Pract. 2021 Oct;226:153611. doi: 10.1016/j.prp.2021.153611. Epub 2021 Sep 13.
GATA binding protein 3 (GATA3) belongs to a family of transcription factors comprising six members. These proteins identify G-A-T-A containing sequences in the target gene and bind to DNA target via two zinc-finger domains. The aim of this study was to evaluate the role of GATA3 in the diagnosis of tumors and its value as a prognostic marker. To perform this review, a comprehensive search was conducted through PubMed, Embase, Scopus, Cochrane and Google Scholar databases from 1985 to 2020. Articles were considered thoroughly by independent reviewers and data were extracted in predefined forms. Final synthesis was conducted by using appropriate data from included articles in each topic. Studies have shown that GATA3 has a critical role in the development of epithelial structures in both embryonic and adult tissues. The majority of studies regarding GATA3 expression in tumor evaluation focused on breast and urothelial neoplasms, whether primary or metastatic. Its sensitivity in these neoplasms has been reported to be high and made this marker more valuable than other available immunohistochemistry markers. However, GATA3 expression was not restricted to these tumors. Studies have shown that GATA3 immunostaining could be a useful tool in various tumors in kidney, salivary gland, endocrine system, hematopoietic system, and skin. GATA3 can also be used as a useful prognostic tool. Although GATA3 is a multi-specific immunohistochemical stain, it is a valuable marker in the panel for confirming many epithelial or mesenchymal neoplasms as both a diagnostic and prognostic tool.
GATA 结合蛋白 3（GATA3）属于转录因子家族，由六个成员组成。这些蛋白质在靶基因中识别含有 G-A-T-A 的序列，并通过两个锌指结构域与 DNA 靶标结合。本研究旨在评估 GATA3 在肿瘤诊断中的作用及其作为预后标志物的价值。为了进行这项综述，通过 PubMed、Embase、Scopus、Cochrane 和 Google Scholar 数据库从 1985 年到 2020 年进行了全面搜索。由独立评审员仔细审查文章，并以预定义的表格形式提取数据。最终综合是通过使用每个主题中包含文章的适当数据进行的。研究表明，GATA3 在胚胎和成人组织中上皮结构的发育中起着关键作用。大多数关于 GATA3 在肿瘤评估中表达的研究都集中在原发性或转移性乳腺和尿路上皮肿瘤上。其在这些肿瘤中的敏感性已被报道很高，这使得该标志物比其他可用的免疫组织化学标志物更有价值。然而，GATA3 的表达并不局限于这些肿瘤。研究表明，GATA3 免疫染色可能是肾脏、唾液腺、内分泌系统、造血系统和皮肤中各种肿瘤的有用工具。GATA3 也可用作有用的预后工具。尽管 GATA3 是一种多特异性免疫组织化学染色，但它是一种有用的标志物，可作为诊断和预后工具，用于确认许多上皮或间充质肿瘤。
