Jacob T J, Karim A K, Thompson G M
Eye Group, St George's Hospital Medical School, Tooting, London.
Eye (Lond). 1987;1 ( Pt 6):722-7. doi: 10.1038/eye.1987.115.
A study of anterior capsules from cataractous lenses revealed that there are marked abnormalities in epithelial structure associated with cataract. In certain cases a distinctive reticulated pattern was observed in whole mounts of the anterior capsule and of these a higher number than expected were from patients receiving steroid medication. In tissue culture experiments it was found that the presence of steroids in the growth medium (10 microM prednisolone) adversely affected the growth of human lens epithelial cells. These observations are consistent with the hypothesis that steroid-induced cataracts are the result of effects on anterior lens epithelial cell function.
一项对白内障晶状体前囊的研究表明，与白内障相关的上皮结构存在明显异常。在某些病例中，在前囊的整装标本中观察到一种独特的网状模式，其中接受类固醇药物治疗的患者出现这种模式的数量高于预期。在组织培养实验中发现，生长培养基中存在类固醇（10微摩尔泼尼松龙）会对人晶状体上皮细胞的生长产生不利影响。这些观察结果与以下假设一致，即类固醇诱导的白内障是对晶状体前上皮细胞功能产生影响的结果。
