人晶状体上皮；与类固醇治疗相关的形态学和超微结构变化。

The human lens epithelium; morphological and ultrastructural changes associated with steroid therapy.

作者信息

Karim A K, Jacob T J, Thompson G M

机构信息

Department of Pharmacology, St George's Hospital Medical School, London.

出版信息

Exp Eye Res. 1989 Feb;48(2):215-24. doi: 10.1016/s0014-4835(89)80071-5.

DOI:10.1016/s0014-4835(89)80071-5

PMID:2924809

Abstract

A distinct disturbance to the structure of the lens epithelium was observed in cataract patients receiving steroid medication. Of those cataract patients receiving steroids, 83% exhibited a reticulated pattern of intercellular clefts compared to 5% in the control group. The reticulated pattern was shown to be due to the presence of gaps between the lateral borders of the epithelial cells by electron microscopy. A significant correlation between steroid therapy and epithelial disruption was demonstrated. The significance of such epithelial disruption to cataract formation is discussed.

摘要

在接受类固醇药物治疗的白内障患者中，观察到晶状体上皮结构出现明显紊乱。在接受类固醇治疗的白内障患者中，83%表现出细胞间裂隙的网状模式，而对照组这一比例为5%。通过电子显微镜观察显示，这种网状模式是由于上皮细胞侧缘之间存在间隙所致。研究表明类固醇治疗与上皮细胞破坏之间存在显著相关性。本文讨论了这种上皮细胞破坏对白内障形成的意义。