Zhou Manli, Yu Yunfeng, Luo Xiaoxin, Wang Jianzhang, Lan Xiaodong, Liu Pei, Feng Yu, Jian Weixiong
College of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine, Changsha, China,
College of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine, Changsha, China.
Cardiology. 2021;146(6):781-792. doi: 10.1159/000518879. Epub 2021 Sep 21.
Coronary arterial disease is the most common cardiovascular disease. Myocardial ischemia-reperfusion injury caused by the initial interruption of organ blood flow and subsequent restoration of organ blood flow is an important clinical problem with various cardiac reperfusion strategies after acute myocardial infarction. Even though blood flow recovery is necessary for oxygen and nutrient supply, reperfusion causes pathological sequelae that lead to the aggravation of ischemic injury. At present, although it is known that injury will occur after reperfusion, clinical treatment always focuses on immediate recanalization. Mitochondrial fusion, fission, biogenesis, autophagy, and their intricate interaction constitute an effective mitochondrial quality control system. The mitochondrial quality control system plays an important role in maintaining cell homeostasis and cell survival. The removal of damaged, aging, and dysfunctional mitochondria is mediated by mitochondrial autophagy. With the help of appropriate changes in mitochondrial dynamics, new mitochondria are produced through mitochondrial biogenesis to meet the energy needs of cells. Mitochondrial dysfunction and the resulting oxidative stress have been associated with the pathogenesis of ischemia/reperfusion (I/R) injury, which play a crucial role in the pathophysiological process of myocardial injury. This review aimed at elucidating the mitochondrial quality control system and establishing the possibility of using mitochondria as a potential therapeutic target in the treatment of I/R injuries.
冠状动脉疾病是最常见的心血管疾病。由器官血流的初始中断及随后的器官血流恢复所导致的心肌缺血-再灌注损伤是急性心肌梗死后各种心脏再灌注策略面临的一个重要临床问题。尽管血流恢复对于氧气和营养物质供应是必要的，但再灌注会引发病理后遗症，导致缺血性损伤加重。目前，虽然已知再灌注后会发生损伤，但临床治疗总是侧重于立即再通。线粒体融合、裂变、生物发生、自噬及其复杂的相互作用构成了一个有效的线粒体质量控制系统。线粒体质量控制系统在维持细胞稳态和细胞存活方面发挥着重要作用。受损、老化和功能失调的线粒体的清除是由线粒体自噬介导的。借助线粒体动力学的适当变化，通过线粒体生物发生产生新的线粒体，以满足细胞的能量需求。线粒体功能障碍及由此产生的氧化应激与缺血/再灌注（I/R）损伤的发病机制有关，其在心肌损伤的病理生理过程中起关键作用。本综述旨在阐明线粒体质量控制系统，并探讨将线粒体作为治疗I/R损伤潜在治疗靶点的可能性。
