Akhavan Zanjani Mohsen, Rahmani Sepideh, Mehranfar Sanaz, Zarrin Milad, Bazyar Hadi, Moradi Poodeh Bahman, Zare Javid Ahmad, Hosseini Seyed Ahmad, Sadeghian Mehdi
Division of Kinesiology, School of Health and Human Performance, Dalhousie University, Halifax, Nova Scotia, Canada.
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Complement Med Res. 2022;29(2):172-181. doi: 10.1159/000519036. Epub 2021 Sep 21.
The primary objective of our study was to systematically review all available prospective cohort studies which investigated the association of soy food intake and incident fracture risk.
We searched PubMed, Scopus, and Embase databases for relevant studies up to June 2021.
Of 695 records, a total of 5 cohort studies were included in the current systematic review. Two studies that were performed in China evaluated hip fracture while 2 studies that were done in Singapore evaluated any kind of fractures. The other study was conducted in Japan and evaluated osteoporosis fractures. All studies used a face-to-face interview to assess the dietary intake of soy foods. All 5 cohort studies were determined to be of high quality. One study considered soy food as a part of a vegetables-fruit-soy food dietary pattern. Others reported the association of dietary intake of soy foods with the risk of fractures.
The evidence from prospective cohort studies was suggestive for a protective role of soy foods, alone or within a dietary pattern, in the risk of incident fracture among Asian women, particularly for those in early menopause and those who used fermented soy products. But for men, the association was not significant. However, more cohort studies, including non-Asian populations, are required to confirm this association fully.
我们研究的主要目的是系统回顾所有已有的前瞻性队列研究，这些研究调查了大豆食品摄入量与骨折发生风险之间的关联。
我们在PubMed、Scopus和Embase数据库中检索截至2021年6月的相关研究。
在695条记录中，共有5项队列研究纳入了当前的系统评价。在中国进行的2项研究评估了髋部骨折，在新加坡进行的2项研究评估了任何类型的骨折。另一项研究在日本进行，评估了骨质疏松性骨折。所有研究均采用面对面访谈来评估大豆食品的饮食摄入量。所有5项队列研究均被判定为高质量。1项研究将大豆食品视为蔬菜-水果-大豆食品饮食模式的一部分。其他研究报告了大豆食品的饮食摄入量与骨折风险之间的关联。
前瞻性队列研究的证据表明，大豆食品单独或在饮食模式中，对亚洲女性发生骨折的风险具有保护作用，特别是对于那些处于绝经早期和食用发酵大豆制品的女性。但对于男性，这种关联并不显著。然而，需要更多的队列研究，包括非亚洲人群，来充分证实这种关联。
