中国人群中HLA - DRw9与重症肌无力的关联。

Association of HLA-DRw9 with myasthenia gravis in Chinese.

作者信息

Chiu H C, Hsieh R P, Hsieh K H, Hung T P

机构信息

Department of Neurology, College of Medicine, National Taiwan University, Taipei, Republic of China.

出版信息

J Immunogenet. 1987 Aug-Oct;14(4-5):203-7. doi: 10.1111/j.1744-313x.1987.tb00382.x.

DOI:10.1111/j.1744-313x.1987.tb00382.x

PMID:3454797

Abstract

HLA phenotypes were studied in 59 Chinese myasthenia gravis (MG) patients. Unfractionated peripheral blood mononuclear cells were used for typing of HLA-A, B and C, and B-enriched lymphocytes for HLA-DR. Seventy-nine healthy subjects were included as controls. When compared with healthy controls, the patients showed significant increases in HLA-Bw46 (47.5% versus 14%, chi 2 = 18.7, P less than 0.001), HLA-DRw9 (59.3% versus 11%, chi 2 = 35.7, P less than 0.001), while HLA-DR3 was decreased (3.4% versus 32.9%, chi 2 = 18.2, P less than 0.001). Further analysis showed that the primary association was with DRw9 and the increase in Bw46 was secondary to it. Both HLA-Bw46 and -DRw9 were increased in all subgroups except where the age of onset was greater than 40 years. Finally, the HLA-A2-Bw46-DRw9 combination was also significantly increased in patients (25.4% versus 5.1%, chi 2 = 11.5, P less than 0.001), especially in the subgroups of MG with age of onset of less than 10 and males with age of onset of less than 40 years.

摘要

对59例中国重症肌无力（MG）患者的HLA表型进行了研究。采用未分离的外周血单个核细胞进行HLA - A、B和C分型，采用富含B淋巴细胞进行HLA - DR分型。纳入79名健康受试者作为对照。与健康对照相比，患者的HLA - Bw46（47.5%对14%，χ2 = 18.7，P < 0.001）、HLA - DRw9（59.3%对11%，χ2 = 35.7，P < 0.001）显著增加，而HLA - DR3降低（3.4%对32.9%，χ2 = 18.2，P < 0.001）。进一步分析表明，主要关联是与DRw9，Bw46的增加是继发于它。除发病年龄大于40岁的亚组外，所有亚组中HLA - Bw46和 - DRw9均增加。最后，患者中HLA - A2 - Bw46 - DRw9组合也显著增加（25.4%对5.1%，χ2 = 11.5，P < 0.001），尤其是发病年龄小于10岁的MG亚组和发病年龄小于40岁的男性亚组。