Hawkins B R, Lam K S, Ma J T, Wang C, Yeung R T
Acta Endocrinol (Copenh). 1987 Apr;114(4):543-6. doi: 10.1530/acta.0.1140543.
The distribution of HLA-A, -B, and -DR antigens in 53 Southern Chinese patients with Hashimoto's thyroiditis including 33 with goitre and 20 without goitre was compared with the distribution in 100 Southern Chinese controls. There was a significantly increased prevalence of HLA Bw46 in the nongoiterous patients and of HLA DRw9 in both groups of patients, but only for HLA DRw9 in the goiterous group was the increase significant after adjustment for the number of antigens studied. Based on these findings and those in other autoimmune diseases it is considered that the haplotype Bw46, DRw9 in Chinese takes the place of B8, DR3 in Caucasians in carrying genes which predispose to the development of auto-immune disease.
对53名患有桥本甲状腺炎的中国南方患者（其中33名有甲状腺肿，20名无甲状腺肿）的HLA - A、- B和 - DR抗原分布情况，与100名中国南方对照者的分布情况进行了比较。无甲状腺肿患者中HLA Bw46的患病率显著增加，两组患者中HLA DRw9的患病率均显著增加，但仅在甲状腺肿组中，经所研究抗原数量校正后，HLA DRw9的增加具有统计学意义。基于这些发现以及其他自身免疫性疾病的研究结果，人们认为在中国人群中，单倍型Bw46、DRw9在携带易患自身免疫性疾病的基因方面，取代了白种人中的B8、DR3。
